Department of Obstetrics and Gynecology, Maternal and Children's Hospital of Shenzhen City, Southern Medical University, Shenzhen, 518000, China.
Department of Cell Biology and Medical Genetics, Shenzhen University Health Science Center, Shenzhen, 518000, China.
Inflamm Res. 2016 Sep;65(9):717-24. doi: 10.1007/s00011-016-0953-y. Epub 2016 May 27.
To investigate the association of polymorphisms in genes involved in coagulation, fibrinolysis, and inflammation with pre-eclampsia (PE) in a Chinese population.
It is a case-control study of patients with PE (n = 117) and controls (n = 286) from the Maternal and Children's Hospital of Shenzhen City carried out between June 2014 and May 2015. The rs6025, rs6020, rs1801133, rs1799963, rs1799889, rs231775, rs1800896, rs1800629, and rs1799724 polymorphisms were analyzed using Snap Shot. Multifactor dimensionality reduction (MDR) and logistic regression analyses were carried out to assess the interactions among these SNPs.
The frequencies of polymorphisms in tumor necrosis factor-α (TNF-α) (rs1800629 and rs1799724) and interleukin 10 (IL-10) (rs1800896) were significantly different between patients with PE and controls (P < 0.05). The best interaction model identified a marginally significant interaction between rs1799724 and rs1800896 (P = 0.05).
This study suggests that polymorphisms in the TNF-α and IL-10 genes could be associated with PE, but additional studies are necessary to explore the mechanisms involving these polymorphisms and the gene-gene interactions involved in the susceptibility to PE.
在中国人群中研究与凝血、纤溶和炎症相关的基因多态性与子痫前期（PE）的关联。
这是一项病例对照研究，纳入了 2014 年 6 月至 2015 年 5 月期间来自深圳市妇幼保健院的 117 例 PE 患者（病例组）和 286 例对照（对照组）。采用 Snap Shot 法检测 rs6025、rs6020、rs1801133、rs1799963、rs1799889、rs231775、rs1800896、rs1800629 和 rs1799724 多态性。采用多因子降维分析（MDR）和 logistic 回归分析评估这些 SNP 之间的相互作用。
肿瘤坏死因子-α（TNF-α）（rs1800629 和 rs1799724）和白细胞介素 10（IL-10）（rs1800896）的多态性在 PE 患者和对照组之间存在显著差异（P<0.05）。最佳交互模型确定 rs1799724 和 rs1800896 之间存在边缘显著的相互作用（P=0.05）。
本研究表明 TNF-α 和 IL-10 基因的多态性可能与 PE 相关，但需要进一步研究以探讨这些多态性涉及的机制以及与 PE 易感性相关的基因-基因相互作用。
