Delattre J Y, Shapiro W R, Posner J B
Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center New York, NY 10021.
J Neurol Sci. 1989 Apr;90(2):147-53. doi: 10.1016/0022-510x(89)90097-x.
To determine the acute effects of low-dose cranial irradiation (CRT) on regional capillary permeability (RCP) of normal brain, brain tumor and damaged brain surrounding the tumor, we used quantitative autoradiography (QAR) to measure regional blood-to-tissue transport (K) of [14C]aminoisobutyric acid (AIB) in experimental C6 brain tumors 3-4 h after a single dose of 3 Gy CRT. K increased 63% in cortex, 30% in basal ganglia and 31% in brain surrounding the tumor (BST) vs. controls (P less than 0.005). K did not change in the tumor or in the brain adjacent to the tumor (BAT), suggesting that capillaries of normal parenchyma are more sensitive to the acute effects of CRT than capillaries of damaged parenchyma or tumor.
为了确定低剂量脑部照射（CRT）对正常脑、脑肿瘤以及肿瘤周围受损脑组织区域毛细血管通透性（RCP）的急性影响，我们使用定量放射自显影术（QAR）来测量在单次3 Gy CRT照射后3 - 4小时，实验性C6脑肿瘤中[¹⁴C]氨基异丁酸（AIB）的区域血 - 组织转运（K）。与对照组相比，皮质中的K增加了63%，基底神经节中的K增加了30%，肿瘤周围脑组织（BST）中的K增加了31%（P < 0.005）。肿瘤或肿瘤邻近脑组织（BAT）中的K没有变化，这表明正常实质的毛细血管比受损实质或肿瘤的毛细血管对CRT的急性影响更敏感。
