Jennekens-Schinkel A, van der Velde E A, Sanders E A, Lanser J B
Neuropsychology Section, State University Leiden, The Netherlands.
J Neurol Sci. 1989 Apr;90(2):187-201. doi: 10.1016/0022-510x(89)90101-9.
Visuospatial problem solving, conceptual reasoning and shifting of set were studied in out-patients with definite and probable MS. The sample of MS patients was homogeneous with respect to 2 important dimensions. All were out-patients, leading a normal although handicap-restricted social life. Furthermore, in all patients relapse or obvious instability of the disease were absent for at least a month. On Raven's Progressive Matrices, the Category test and the Wisconsin Modified Card Sorting test, no significant differences were found between the group of MS patients and a control group of healthy volunteers. However, 18% of MS patients and 4% of controls were rated as performing slightly below the expected levels of cognition. Stepwise regression analysis failed to reveal effects of illness variables, and no difference between patients with definite and probable MS could be detected. Clearly, most socially integrated MS patients in stable disease stages are capable of normal visuospatial problem solving, abstract reasoning and shifting of set.
对确诊为多发性硬化症（MS）和疑似MS的门诊患者进行了视觉空间问题解决能力、概念推理能力和定势转换能力的研究。MS患者样本在两个重要维度上具有同质性。所有患者均为门诊患者，尽管生活受到残疾限制，但仍过着正常的社会生活。此外，所有患者至少一个月内没有疾病复发或明显病情不稳定的情况。在瑞文渐进性矩阵测验、类别测验和威斯康星修订卡片分类测验中，MS患者组与健康志愿者对照组之间未发现显著差异。然而，18%的MS患者和4%的对照组被评定为认知表现略低于预期水平。逐步回归分析未能揭示疾病变量的影响，也未检测到确诊MS患者和疑似MS患者之间的差异。显然，大多数处于疾病稳定阶段且融入社会的MS患者能够正常地解决视觉空间问题、进行抽象推理和实现定势转换。
