Troyer A K, Fisk J D, Archibald C J, Ritvo P G, Murray T J
Camp Hill Medical Centre, Halifax, Nova Scotia, Canada.
J Clin Exp Neuropsychol. 1996 Apr;18(2):211-9. doi: 10.1080/01688639608408276.
A number of intercorrelated factors, including level of neurologic impairment, age, and conceptual reasoning, appear to be related to memory performance among patients with Multiple Sclerosis (MS). A battery of neuropsychological tests was administered to 131 patients with MS ranging in age from 19 to 76 years, with a mean symptom duration of 12.3 years and an overall mild level of MS-related neurologic impairment. Regression analyses indicated that neurologic impairment and age each contributed uniquely to the prediction of delayed free recall of a word list. Furthermore, when the effect of conceptual reasoning was accounted for, neither neurologic impairment nor age were significantly related to recall. Thus, a mediated relation was confirmed, supporting the idea that a significant portion of neurologic-impairment-related and age-related differences in recall are due to differences in conceptual reasoning that are important for optimal performance on tests of recall. Additional analyses failed to support a similar mediated relation using recognition rather than recall as the measure of memory performance.
包括神经功能损害程度、年龄和概念推理在内的一些相互关联的因素，似乎与多发性硬化症（MS）患者的记忆表现有关。对131名年龄在19至76岁之间的MS患者进行了一系列神经心理学测试，这些患者的平均症状持续时间为12.3年，MS相关神经功能损害总体处于轻度水平。回归分析表明，神经功能损害和年龄各自对单词列表延迟自由回忆的预测有独特贡献。此外，当考虑概念推理的影响时，神经功能损害和年龄与回忆均无显著关联。因此，证实了一种中介关系，支持了这样一种观点，即与神经功能损害相关和与年龄相关的回忆差异的很大一部分是由于概念推理的差异，而概念推理对于回忆测试的最佳表现很重要。使用识别而非回忆作为记忆表现的衡量指标的其他分析未能支持类似的中介关系。
