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通过初级卫生保健提供的多种微量营养素粉剂可减少亚马逊地区幼儿的铁和维生素A缺乏症。

Multiple micronutrients in powder delivered through primary health care reduce iron and vitamin A deficiencies in young Amazonian children.

作者信息

Oliveira Cristieli Sm, Sampaio Patrícia, Muniz Pascoal T, Cardoso Marly A

机构信息

1Public Health Nutrition Program,School of Public Health,University of São Paulo,São Paulo,Brazil.

2Centre of Health Sciences and Sport,Federal University of Acre,Rio Branco,Brazil.

出版信息

Public Health Nutr. 2016 Nov;19(16):3039-3047. doi: 10.1017/S1368980016001294. Epub 2016 May 30.

Abstract

OBJECTIVE

We evaluated the effect of home fortification with multiple micronutrient powder (MNP) on anaemia and micronutrient status of young Amazonian children.

DESIGN

A pragmatic controlled trial was performed. A control group (CG) of children aged 11-14 months was recruited in the routine of primary health-care centres for assessing anaemia and micronutrient status. At the same time, an intervention group (IG) of infants aged 6-8 months was recruited in the same health centres to receive MNP daily in complementary feeding for 2 months. The IG children were assessed 4-6 months after enrolment (n 112) when they had reached the age of the CG participants (n 128) for comparisons.

SETTING

Primary health centres in Rio Branco city, Brazilian Amazon.

SUBJECTS

A total of 240 children aged<2 years.

RESULTS

In the CG, the prevalence of anaemia (Hb8·3 mg/l) and vitamin A deficiency (VAD; serum retinol <0·70 μmol/l) was 20·3 %, 72·4 % and 18·6 %, respectively. Among the IG participants (aged 11-14 months), the prevalence of anaemia, ID and VAD was 15·2 %, 25·2 % and 4·7 %, respectively. The IG had a lower likelihood of ID (prevalence ratio (95 % CI): 0·34 (0·24, 0·49)) and VAD (0·25 (0·09, 0·64)).

CONCLUSIONS

Home fortification of complementary feeding delivered through primary health care was effective in reducing iron and vitamin A deficiencies among young Amazonian children.

摘要

目的

我们评估了用多种微量营养素粉(MNP)进行家庭强化对亚马逊地区幼儿贫血及微量营养素状况的影响。

设计

开展了一项实用的对照试验。在初级保健中心的日常工作中招募了11 - 14个月大的儿童作为对照组(CG),以评估贫血和微量营养素状况。与此同时,在同一保健中心招募了6 - 8个月大的婴儿作为干预组(IG),在辅食喂养中每日接受MNP,为期2个月。IG组儿童在入组后4 - 6个月(n = 112)进行评估,此时他们达到了CG组参与者(n = 128)的年龄,以便进行比较。

地点

巴西亚马逊地区里奥布兰科市的初级保健中心。

研究对象

共有240名2岁以下儿童。

结果

在CG组中,贫血(血红蛋白<110 g/l)、铁缺乏(ID;血清铁蛋白<12 μg/l)和维生素A缺乏(VAD;血清视黄醇<0.70 μmol/l)的患病率分别为20.3%、72.4%和18.6%。在IG组参与者(11 - 14个月大)中,贫血、ID和VAD的患病率分别为15.2%、25.2%和4.7%。IG组患ID(患病率比(95%CI):0.34(0.24,0.49))和VAD(0.25(0.09,0.64))的可能性较低。

结论

通过初级保健进行辅食的家庭强化对减少亚马逊地区幼儿的铁和维生素A缺乏有效。

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