Deep Aakash, Bhatia Richa Kaur, Kaur Ramanjot, Kumar Sanjiv, Jain Upendra Kumar, Singh Harinder, Batra Sandeep, Kaushik Dinesh, Deb Pran Kishore
Department of Pharmaceutical Chemistry, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
Curr Top Med Chem. 2017;17(2):238-250. doi: 10.2174/1568026616666160530153233.
Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities. This scaffold has also been represented in various marketed preparations such as zolimidine, zolpidem, alpidem. Therefore, several attempts were made to carry out the structural modifications of this scaffold to discover and develop novel therapeutic agents. This review provides a valuable insight into the research findings of wide range of derivatives of imidazo[1,2-a]pyridine scaffold leading to promising heterocyclic compounds which could be explored further for the synthesis of new derivatives as well as construction of potential drug-like chemical libraries for biological screening in search of new therapeutic agents.
咪唑并[1,2 - a]吡啶是最具潜力的双环5 - 6杂环之一，因其在药物化学领域的广泛应用，如抗癌、抗分枝杆菌、抗利什曼原虫、抗惊厥、抗菌、抗病毒、抗糖尿病、质子泵抑制剂、杀虫活性等，而被视为一种“药物偏好”骨架。这种骨架也存在于各种市售制剂中，如佐利米定、唑吡坦、阿吡坦。因此，人们进行了多次尝试对该骨架进行结构修饰，以发现和开发新型治疗药物。本综述对咪唑并[1,2 - a]吡啶骨架的多种衍生物的研究结果提供了有价值的见解，这些衍生物可生成有前景的杂环化合物，可进一步探索用于合成新的衍生物，以及构建潜在的类药物化学库用于生物筛选，以寻找新的治疗药物。
