Enguehard-Gueiffier Cécile, Gueiffier Alain
Laboratory of Medicinal Chemistry, Faculty of Pharmacy, 31 Avenue Monge, 37200 Tours, France.
Mini Rev Med Chem. 2007 Sep;7(9):888-99. doi: 10.2174/138955707781662645.
Imidazo[1,2-a]pyridine is a bicyclic system with a bridgehead nitrogen atom, of growing interest in medicinal chemistry. The paper deals with the recent progress realised in the comprehension of the pharmacological properties of this scaffold. From the many imidazo[1,2-a]pyridine analogues described in the literature, those discussed herein will be presented in three parts concerning first the enzyme inhibitors, then the receptor ligands and finally the anti-infectious agents.
咪唑并[1,2 - a]吡啶是一种具有桥头氮原子的双环体系，在药物化学领域的关注度日益增加。本文论述了在理解该骨架的药理特性方面所取得的最新进展。从文献中描述的众多咪唑并[1,2 - a]吡啶类似物来看，本文所讨论的那些将分为三个部分进行介绍，首先是酶抑制剂，其次是受体配体，最后是抗感染药物。
