The influence of intensive lifestyle intervention on patients with isolated impaired fasting glucose: a meta-analysis.

AIM

To evaluate the effect of intensive lifestyle intervention on patients with isolated impaired fasting glucose.

BACKGROUND

The application of lifestyle intervention to clinical nursing can help improve outcomes of patients with impaired fasting glucose.

DESIGN

We performed a meta-analysis of randomized controlled trials using methods outlined in the Cochrane Handbook.

METHODS

We performed keyword searches of the literature databases up to September 2014 and performed manual searches of selected article reference lists. Data were extracted by the lead reviewer, cross-checked by the second reviewer, entered into RevMan5·3, and pooled and analysed using the fixed effect inverse-variance model or random effects model to determine the mean difference and calculate the weighted mean difference. The heterogeneity statistic (I ), overall effect (Z) and P-value were calculated.

RESULTS

A total of five studies were included in our analysis. Following the heterogeneity test statistic, overall effect Z score with P-value was calculated. The targets of fasting plasma glucose, weight, body mass index, triglycerides, high-density lipoprotein cholesterol and total cholesterol all showed significant differences between the intervention and control groups.

CONCLUSION

Lifestyle intervention can improve glycaemic control in patients with isolated impaired fasting glucose. It also reduces blood-lipid levels and promotes weight loss. Larger patient cohorts and adequate follow-up should be included in future trials.