Yang Xiu-Juan, Zou Shu-Fang, Xu Yong, Li Yi, Yang Shan-Shan
Southwest Medical University School of Nursing, Luzhou, China.
The Affiliated Hospital of Southwest Medical University, Luzhou, China.
J Adv Nurs. 2016 Nov;72(11):2587-2597. doi: 10.1111/jan.13015. Epub 2016 May 29.
To evaluate the effect of intensive lifestyle intervention on patients with isolated impaired fasting glucose.
The application of lifestyle intervention to clinical nursing can help improve outcomes of patients with impaired fasting glucose.
We performed a meta-analysis of randomized controlled trials using methods outlined in the Cochrane Handbook.
We performed keyword searches of the literature databases up to September 2014 and performed manual searches of selected article reference lists. Data were extracted by the lead reviewer, cross-checked by the second reviewer, entered into RevMan5·3, and pooled and analysed using the fixed effect inverse-variance model or random effects model to determine the mean difference and calculate the weighted mean difference. The heterogeneity statistic (I ), overall effect (Z) and P-value were calculated.
A total of five studies were included in our analysis. Following the heterogeneity test statistic, overall effect Z score with P-value was calculated. The targets of fasting plasma glucose, weight, body mass index, triglycerides, high-density lipoprotein cholesterol and total cholesterol all showed significant differences between the intervention and control groups.
Lifestyle intervention can improve glycaemic control in patients with isolated impaired fasting glucose. It also reduces blood-lipid levels and promotes weight loss. Larger patient cohorts and adequate follow-up should be included in future trials.
评估强化生活方式干预对单纯空腹血糖受损患者的影响。
将生活方式干预应用于临床护理有助于改善空腹血糖受损患者的治疗效果。
我们采用Cochrane手册中概述的方法对随机对照试验进行了荟萃分析。
我们对截至2014年9月的文献数据库进行了关键词检索，并对选定文章的参考文献列表进行了手工检索。数据由第一作者提取，第二作者进行交叉核对，录入RevMan5·3，并使用固定效应逆方差模型或随机效应模型进行汇总和分析，以确定平均差异并计算加权平均差异。计算异质性统计量（I²）、总体效应（Z）和P值。
我们的分析共纳入五项研究。在进行异质性检验统计后，计算了总体效应Z评分和P值。干预组和对照组在空腹血糖、体重、体重指数、甘油三酯、高密度脂蛋白胆固醇和总胆固醇等指标上均显示出显著差异。
生活方式干预可改善单纯空腹血糖受损患者的血糖控制。它还能降低血脂水平并促进体重减轻。未来的试验应纳入更大的患者队列并进行充分的随访。
