Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, 6 Semmelweis Str., 6725 Szeged, Hungary.
Department of Neurology, Ferenc Jahn Hospital of South-Pest, 1 Köves Road, 1204 Budapest, Hungary.
Mult Scler Relat Disord. 2016 May;7:26-32. doi: 10.1016/j.msard.2016.02.006. Epub 2016 Feb 12.
The common symptoms of multiple sclerosis are fatigue, depression, cognitive dysfunction, pain and sexual dysfunction, which influence the health-related quality of life of the patients.
We aimed to determine the correlations between the health-related quality of life, the level of disability, fatigue and depression in glatiramer acetate-treated patients with multiple sclerosis in Hungary.
The Hungarian versions of the Multiple Sclerosis Quality of Life-54, Fatigue Impact Scale and Beck Depression Inventory questionnaires were completed by 428 relapsing-remitting multiple sclerosis patients treated with glatiramer acetate from 19 Hungarian centers.
The prevalence of fatigue was found to be 62.4%. The prevalence of depression was lower (13.4%) than that described in previous studies (36-54%) among patients with multiple sclerosis. Significant differences in the health-related quality of life were found between fatigued and non-fatigued patients. The level of disability, fatigue, depression and the duration of the disease correlated significantly with the quality of life. However, linear regression analysis indicated that the quality of life was predicted by the level of disability, depression, social and cognitive fatigue, but not by physical fatigue.
Decreasing the disease activity in multiple sclerosis with immunomodulatory therapy, together with improvements of the diagnostics and treatment of the accompanying depression and fatigue are of high priority to improve the health-related quality of life of patients with multiple sclerosis.
多发性硬化症的常见症状包括疲劳、抑郁、认知功能障碍、疼痛和性功能障碍，这些症状会影响患者的健康相关生活质量。
我们旨在确定匈牙利接受醋酸格拉替雷治疗的多发性硬化症患者的健康相关生活质量、残疾程度、疲劳和抑郁之间的相关性。
来自 19 个匈牙利中心的 428 名接受醋酸格拉替雷治疗的复发性缓解型多发性硬化症患者完成了匈牙利版本的多发性硬化症生活质量 54 项、疲劳影响量表和贝克抑郁量表问卷。
发现疲劳的患病率为 62.4%。与多发性硬化症患者中先前研究（36-54%）描述的相比，抑郁的患病率较低（13.4%）。疲劳患者和非疲劳患者的健康相关生活质量存在显著差异。残疾程度、疲劳、抑郁和疾病持续时间与生活质量显著相关。然而，线性回归分析表明，生活质量由残疾程度、抑郁、社会和认知疲劳预测，但不受身体疲劳的影响。
通过免疫调节治疗降低多发性硬化症的疾病活动，以及改善伴随的抑郁和疲劳的诊断和治疗，对于提高多发性硬化症患者的健康相关生活质量具有重要意义。
