粪便潜血检测在结直肠癌筛查中的诊断价值。
Diagnostic value of occult fecal blood testing for colorectal cancer screening.
作者信息
Chen K, Jiao D A, Zheng S, Zhou L, Yu H, Yuan Y C, Yao K Y, Ma X Y, Zhang Y
机构信息
Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China.
出版信息
World J Gastroenterol. 1997 Sep 15;3(3):166-8. doi: 10.3748/wjg.v3.i3.166.
AIM
To evaluate the diagnostic value of occult fecal blood testing in mass colorectal cancer screening.
METHODS
A reverse passive hemagglutination reaction fecal occult blood test (RPHA-FOBT) and colorectal cancer risk factor quantitative method were used as preliminary screening for colorectal cancer. A 60-cm fiber optic colonoscopy was used to validate the preliminary screen and was used to detect colorectal cancer in a community of 75813 subjects.
RESULTS
Compared to the 60-cm fiber optic colonoscopy as a standard reference, FOBT has a sensitivity of 41.9%, specificity of 95.8%, Youden's index of 0.38, and positive predictive value of 0.68%. These results increased with subject age from the first detection. A 3-year follow up in the target mass showed that all new cases had initially been FOBT-negative.
CONCLUSION
The value of FOBT as an indicator of colorectal cancer in mass screening is limited.
目的
评估粪便潜血检测在大规模结直肠癌筛查中的诊断价值。
方法
采用反向被动血凝反应粪便潜血试验（RPHA-FOBT）和结直肠癌危险因素定量方法对结直肠癌进行初步筛查。使用60厘米纤维结肠镜对初步筛查进行验证，并用于检测75813名受试者社区中的结直肠癌。
结果
与作为标准参考的60厘米纤维结肠镜相比，粪便潜血检测的灵敏度为41.9%，特异度为95.8%，约登指数为0.38，阳性预测值为0.68%。这些结果从首次检测起随受试者年龄增加。对目标人群进行3年随访显示，所有新病例最初粪便潜血检测均为阴性。
结论
粪便潜血检测作为大规模筛查中结直肠癌指标的价值有限。
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