梗阻性黄疸中胆汁酸与心肌损伤的关系。
Relation between bile acids and myocardial damage in obstructive jaundice.
作者信息
Mu Y P, Peng S Y
机构信息
Yi-Ping Mu, Shu-You Peng, Department of Surgery, Second Affiliated Hospital, Zhejiang Medical University, Hangzhou 310009, Zhejiang Province, China.
出版信息
World J Gastroenterol. 1997 Sep 15;3(3):174-6. doi: 10.3748/wjg.v3.i3.174.
AIM
To investigate the morphologic changes of the myocardium and its relationship to serum bile acids in obstructive jaundice.
METHODS
Part 1: 35 rats were randomly assigned to three groups: Group I (BDL1, n = 11), the common bile duct (CBD) was ligated and severed and mice were then sacrificed after one week. Group I (BDL2, n = 11), the CBD was ligated and severed and mice were then killed after two weeks. Group I (SO, n = 13), the CBD was isolated. Hearts were collected for morphologic studies and blood was taken to determine the total serum bile acids (TAB). Part 2: 13 rats received gastric intubation of 10% 4 mL/kg sodium cholate. Their serum TBA and the heart's morphologic changes were then examined.
RESULTS
One to two weeks after the CBD was ligated and severed, damage was evident in the mitochondria within the myocardium and the serum TBA was significantly increased. When rats were administered sodium cholate to make their peak blood concentration mimic the average blood concentration in BDL2, a similar degree of myocardial damage was observed.
CONCLUSION
An increase in endogenous bile acids is one causative factor of myocardial damage in obstructive jaundice.
目的
探讨梗阻性黄疸时心肌的形态学变化及其与血清胆汁酸的关系。
方法
第一部分：35只大鼠随机分为三组：I组（BDL1，n = 11），结扎并切断胆总管，一周后处死小鼠。II组（BDL2，n = 11），结扎并切断胆总管，两周后处死小鼠。III组（SO，n = 13），分离胆总管。收集心脏进行形态学研究，并取血测定血清总胆汁酸（TAB）。第二部分：13只大鼠经胃管注入10% 4 mL/kg胆酸钠。然后检测其血清TBA及心脏的形态学变化。
结果
结扎并切断胆总管1至2周后，心肌内线粒体出现明显损伤，血清TBA显著升高。当给大鼠注射胆酸钠使其血药峰浓度模拟BDL2组的平均血药浓度时，观察到了相似程度的心肌损伤。
结论
内源性胆汁酸增加是梗阻性黄疸时心肌损伤的一个致病因素。
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