Teipel Stefan J, Bruno Davide, Grothe Michel J, Nierenberg Jay, Pomara Nunzio
German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany; Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany.
Department of Psychology, Liverpool Hope University, Liverpool, UK.
Alzheimers Dement (Amst). 2015 May 7;1(2):216-9. doi: 10.1016/j.dadm.2015.01.007. eCollection 2015 Jun.
Volumes of hippocampus and cholinergic basal forebrain are associated with delayed recall performance and may modulate the effect of a muscarinic receptor antagonist on delayed recall in healthy volunteers.
We studied 15 older adults before and after the oral administration of a single dose of 1 or 2 mg of the preferential M1 muscarinic receptor antagonist trihexyphenidyl (Artane™) or placebo in a double-blind randomized cross-over design. Hippocampus and basal forebrain volumes were measured using magnetic resonance imaging.
We found a significant interaction between treatment and hippocampus volume and a trend level effect between treatment and anterior basal forebrain volume on task performance, with an attenuation of the association between volume size and performance with trihexyphenidyl.
These findings suggest a reduction of delayed recall performance with increasing doses of the muscarinic antagonist that is related to an uncoupling of the association of task performance with cholinergic basal forebrain and hippocampus volumes.
海马体和胆碱能基底前脑的体积与延迟回忆表现相关，并且可能调节毒蕈碱受体拮抗剂对健康志愿者延迟回忆的影响。
我们采用双盲随机交叉设计，对15名老年人在口服单剂量1毫克或2毫克的选择性M1毒蕈碱受体拮抗剂苯海索（安坦™）或安慰剂之前和之后进行了研究。使用磁共振成像测量海马体和基底前脑的体积。
我们发现治疗与海马体体积之间存在显著交互作用，并且治疗与前基底前脑体积之间对任务表现有趋势水平效应，使用苯海索时体积大小与表现之间的关联减弱。
这些发现表明，随着毒蕈碱拮抗剂剂量增加，延迟回忆表现降低，这与任务表现与胆碱能基底前脑和海马体体积之间的关联解耦有关。
