Sillanpää Saara, Sipilä Markku, Hyöty Heikki, Rautiainen Markus, Laranne Jussi
Department of Anatomy, School of Medicine, University of Tampere, 33520 Tampere, Finland; Department of Otorhinolaryngology and Head and Neck Surgery, Tampere University Hospital and School of Medicine, University of Tampere, 33520 Tampere, Finland.
Department of Otorhinolaryngology and Head and Neck Surgery, Tampere University Hospital and School of Medicine, University of Tampere, 33520 Tampere, Finland.
Int J Pediatr Otorhinolaryngol. 2016 Jun;85:91-4. doi: 10.1016/j.ijporl.2016.03.037. Epub 2016 Apr 11.
Microbiology and susceptibility of middle ear pathogens in children change over time and antibiotic resistance is increasing globally. For the clinicians it is important to be up to date about the resistance situation when considering antibiotic treatment in acute otitis media (AOM). In this study we analysed the resistance profile of AOM pathogens in out-patient children in Finland.
A total of 41 culture positive middle ear fluid (MEF) samples were analysed for bacteria and the presence of antibiotic resistant strains. The samples were obtained from children aged six - 39 months who participated in the otitis media trial during one year period.
The most common pathogen was Haemophilus influenzae 17 (40%), followed by Streptococcus pneumoniae in 15 (35%) and Moraxella catarrhalis in 8 (19%). Other pathogens were detected in 3 (7%) of cases. Antibiotic resistance or diminished sensitivity was seen in 63% of the detected bacteria and 28% of pathogens produced beta-lactamase.
Antibiotic resistant bacterial strains causing AOM have increased in Finland. Nevertheless, most of the pathogens (72%) were sensitive to amoxicillin, which is still recommended as the first line antibiotic in the treatment of AOM.
儿童中耳病原体的微生物学特性及药敏情况会随时间变化，且全球范围内抗生素耐药性不断增加。对于临床医生而言，在考虑急性中耳炎（AOM）的抗生素治疗时，及时了解耐药情况至关重要。在本研究中，我们分析了芬兰门诊儿童AOM病原体的耐药情况。
共对41份培养阳性的中耳积液（MEF）样本进行细菌及抗生素耐药菌株检测。样本取自6至39个月大、在一年期间参与中耳炎试验的儿童。
最常见的病原体是流感嗜血杆菌17例（40%），其次是肺炎链球菌15例（35%）和卡他莫拉菌8例（19%）。3例（7%）病例检测到其他病原体。63%的检测细菌存在抗生素耐药或敏感性降低情况，28%的病原体产生β-内酰胺酶。
芬兰引起AOM的抗生素耐药菌株有所增加。然而，大多数病原体（72%）对阿莫西林敏感，阿莫西林仍是AOM治疗中推荐的一线抗生素。
