Lee Seung-Hun, Yoon Jong-Min, Kim Young-Hoo, Jeong Dong-Gu, Park Soobong, Kang Dae-Jung
Research Laboratories, Ildong Pharmaceutical, 20, Samsung 1-ro 1-gil, Hwaseong 18449.
Department of Biotechnology and Bioengineering, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Microbiol Immunol. 2016 Jul;60(7):468-76. doi: 10.1111/1348-0421.12390.
The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice were investigated. After induction of dermatitis in NC/Nga mice with house-dust mite extract, each group was fed RHT3201 with 1 × 10(8) , 1 × 10(9) , or 1 × 10(10) cells orally once a day for 8 weeks. Dermatitis scores and frequency of scratching were improved by oral feeding with RHT3201. In contrast to the control group, RHT3201-fed mice showed significantly down-regulated mast cell numbers and serum immunoglobulin E (IgE) concentrations had significantly less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 was found to be dose-dependent. These findings indicate that RHT3201 has potential for treating AD.
研究了口服鼠李糖乳杆菌IDCC 3201 间歇灭菌产物（RHT3201）对NC/Nga小鼠特应性皮炎（AD）样皮肤损伤的治疗效果。在用屋尘螨提取物诱导NC/Nga小鼠发生皮炎后，每组小鼠每天口服一次含有1×10⁸、1×10⁹或1×10¹⁰个细胞的RHT3201，持续8周。口服RHT3201可改善皮炎评分和搔抓频率。与对照组相比，喂食RHT3201的小鼠肥大细胞数量显著下调，血清免疫球蛋白E（IgE）浓度显著降低，其腋窝淋巴结细胞中的白细胞介素4（IL4）也显著减少。发现RHT3201的治疗效果具有剂量依赖性。这些发现表明RHT3201具有治疗AD的潜力。
