手性Ru(ii)-Amm-Pheox配合物催化重氮Weinreb酰胺的高度立体选择性环丙烷化反应。
Highly stereoselective cyclopropanation of diazo Weinreb amides catalyzed by chiral Ru(ii)-Amm-Pheox complexes.
作者信息
Chanthamath Soda, Mandour Hamada S A, Tong Thu Minh Thi, Shibatomi Kazutaka, Iwasa Seiji
机构信息
Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan.
出版信息
Chem Commun (Camb). 2016 Jun 14;52(50):7814-7. doi: 10.1039/c6cc02498j.
PMID:27240664
Abstract
The first highly stereoselective cyclopropanation of diazo Weinreb amides with olefins was accomplished using chiral Ru(ii)-Amm-Pheox complex to give the corresponding chiral cyclopropyl Weinreb amides in high yields (up to 99%) with excellent diastereoselectivities (up to 99 : 1 dr) and enantioselectivities (up to 96% ee).
摘要
利用手性钌（II）-氨-苯氧基络合物实现了重氮威纳酰胺与烯烃的首次高度立体选择性环丙烷化反应，以高收率（高达99%）得到相应的手性环丙基威纳酰胺，具有优异的非对映选择性（高达99∶1的dr值）和对映选择性（高达96%的ee值）。
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