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N-乙酰半胱氨酸治疗隔布树中毒:两例儿童病例报告

N-acetylcysteine in Cleistanthus collinus Poisoning: A Report of Two Cases in Children.

作者信息

Sharma Shreya, Rameshkumar Ramachandran, Mahadevan Subramanian

机构信息

Department of Pediatrics, JIPMER, Puducherry, India - 605 006

Department of Pediatrics, JIPMER, Puducherry, India - 605 006.

出版信息

J Trop Pediatr. 2016 Dec;62(6):487-489. doi: 10.1093/tropej/fmw030. Epub 2016 May 29.

DOI:10.1093/tropej/fmw030
PMID:27240665
Abstract

Cleistanthus collinus, also known as Oduvanthalai in Tamil, is the most commonly encountered plant poison in southern India. The leaves are used for poisoning humans (suicide or homicide) and animals (cattle and fish) and as an abortifacient, especially in rural south India. Although this poisoning is commonly reported in adults, data regarding the use of N-acetylcysteine in pediatric poisoning is lacking. We report two previously healthy male siblings of pediatric age group who ingested the liquid extracted from crushed leaves of this plant given to them by their mother as a means of deliberate harm. Both patients developed distal renal tubular acidosis, with hypokalemia. The younger sibling also developed myocardial toxicity. Other significant findings noted include hypocalcemia, hypomagnesemia and elevated liver enzymes. Both patients received supportive care along with N-acetylcysteine infusion, and showed complete recovery within 10 days.

摘要

棒柄花,在泰米尔语中也被称为奥杜万塔莱,是印度南部最常见的植物性毒物。其叶子被用于毒害人类(自杀或他杀)和动物(牛和鱼),还被用作堕胎药,尤其在印度南部农村地区。虽然这种中毒情况在成年人中常有报道,但关于儿童中毒时使用N - 乙酰半胱氨酸的数据却很缺乏。我们报告了两名来自儿童年龄组的此前健康的男性同胞,他们摄入了母亲作为蓄意伤害手段给他们的从这种植物碾碎的叶子中提取的液体。两名患者均出现了远端肾小管酸中毒并伴有低钾血症。年幼的同胞还出现了心肌毒性。其他显著发现包括低钙血症、低镁血症和肝酶升高。两名患者均接受了支持治疗并输注了N - 乙酰半胱氨酸,10天内完全康复。

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