Pai S M, Melethil S
University of Missouri-Kansas City, School of Pharmacy 64108-2792.
J Pharm Sci. 1989 Mar;78(3):200-2. doi: 10.1002/jps.2600780305.
Aluminum (Al) kinetics after intravenous bolus administration were studied in the rat. The animals received either 0.1 or 1.0 mg/kg (n = 6 at each dose) of elemental Al as the sulfate salt. The Al content of serial blood samples was determined by flameless atomic absorption spectrophotometry. Blood and plasma Al-time profiles after both doses were monoexponential in most cases. Increasing the administered dose increased the elimination half-life (mean +/- SD) from 1.20 +/- 0.25 to 2.41 +/- 0.26 h. A corresponding decrease in systemic clearance was observed (49.6 +/- 11.0 to 18.4 +/- 4.6 mL/kg.h). Both changes were significant (p less than 0.05). Significant differences were also observed in the volume of distribution, the values of which were 78.3 +/- 17.2 and 58.9 +/- 8.5 mL/kg at the low and high doses, respectively. At both doses, blood:plasma ratios ranged from 0.8 to 1.0, indicating considerable uptake/binding of the element by blood cells.
在大鼠中研究了静脉推注给药后铝（Al）的动力学。动物接受0.1或1.0mg/kg（每组剂量n = 6）的元素铝作为硫酸盐。通过无火焰原子吸收分光光度法测定系列血样中的铝含量。在大多数情况下，两种剂量后的血液和血浆铝-时间曲线均为单指数形式。增加给药剂量使消除半衰期（平均值±标准差）从1.20±0.25小时增加到2.41±0.26小时。观察到全身清除率相应降低（从49.6±11.0降至18.4±4.6mL/kg·h）。这两个变化均具有显著性（p小于0.05）。在分布容积方面也观察到显著差异，低剂量和高剂量时的值分别为78.3±17.2和58.9±8.5mL/kg。在两种剂量下，血：浆比值范围为0.8至1.0，表明该元素被血细胞大量摄取/结合。
