Gupta S K, Waters D H, Gwilt P R
J Pharm Sci. 1986 Jun;75(6):586-9. doi: 10.1002/jps.2600750613.
The kinetics of aluminum were determined in the rat. Intravenous bolus and oral doses of 8.1-mg/kg of aluminum as the chloride salt were administered to six rats. Serial blood samples and total urine and feces were collected and assayed for aluminum by atomic absorption spectrophotometry. The fraction absorbed orally (mean +/- SEM) was 0.27 +/- 0.03; the half-life was 5.29 +/- 0.47 h; the steady-state volume of distribution was 38.4 +/- 6.4 mL/kg, and the clearance was 8.87 +/- 1.76 mL X h-1 X kg-1. It was found that aluminum did not significantly penetrate the cellular components of blood. Plasma protein binding was determined to be approximately 98%. Sixty percent of the intravenous dose was excreted in the urine and the remaining 40% was excreted in the feces.
在大鼠体内测定了铝的动力学。给6只大鼠静脉推注和口服8.1毫克/千克氯化铝盐形式的铝。采集系列血样以及全部尿液和粪便，并用原子吸收分光光度法测定其中的铝含量。经口吸收分数（平均值±标准误）为0.27±0.03；半衰期为5.29±0.47小时；稳态分布容积为38.4±6.4毫升/千克，清除率为8.87±1.76毫升·小时⁻¹·千克⁻¹。研究发现，铝不会显著渗透到血液的细胞成分中。血浆蛋白结合率测定为约98%。静脉注射剂量的60%经尿液排出，其余40%经粪便排出。
