Dahn Cassidy M, Manasco A Travis, Breaud Alan H, Kim Samuel, Rumas Natalia, Moin Omer, Mitchell Patricia M, Nelson Kerrie P, Baker William, Feldman James A
Boston Medical Center, Emergency Medicine, Boston, MA, USA.
Boston Medical Center, Emergency Medicine, Boston, MA, USA; Boston University School of Medicine, Boston, MA, USA.
Am J Emerg Med. 2016 Aug;34(8):1505-10. doi: 10.1016/j.ajem.2016.05.009. Epub 2016 May 11.
Unplanned intensive care unit (ICU) transfer (UIT) within 48 hours of emergency department (ED) admission increases morbidity and mortality. We hypothesized that a majority of UITs do not have critical interventions (CrIs) and that CrI is associated with worse outcomes.
The objective of the study is to characterize all UITs (including patients who died before ICU transfer), the proportion with CrI, and the effect of having CrI on mortality.
This is a single-center, retrospective cohort study of UITs within 48 hours from 2008 to 2013 at an urban academic medical center and included patients 18 years or older without advanced directives (ADs). Critical intervention was defined by modified Delphi process. Data included demographics, comorbidities, reasons for UIT, length of stay, CrIs, and mortality. We calculated descriptive statistics with 95% confidence intervals (CIs).
A total of 837 (0.76%) of 108 732 floor admissions from the ED had a UIT within 48 hours; 86 admitted patients died before ICU. We excluded 23 ADs, 117 postoperative transfers, 177 planned ICU transfers, and 4 with missing data. Of the 516 remaining, 65% (95% CI, 61%-69%) received a CrI. Unplanned ICU transfer reasons are as follows: 33 medical errors, 90 disease processes not present on arrival, and 393 clinical deteriorations. Mortality was 10.5% (95% CI, 8%-14%), and mean length of stay was 258 hours (95% CI, 233-283) for those with CrI, whereas the mortality was 2.8% (95% CI, 1%-6%) and mean length of stay was 177 hours (95% CI, 157-197) for those without CrI.
Unplanned ICU transfer is rare, and only 65% had a CrI. Those with CrI had increased morbidity and mortality.
急诊科(ED)入院48小时内的非计划重症监护病房(ICU)转院(UIT)会增加发病率和死亡率。我们假设大多数UIT没有关键干预措施(CrI),且CrI与更差的结局相关。
本研究的目的是描述所有UIT(包括在ICU转院之前死亡的患者)、有CrI的比例以及CrI对死亡率的影响。
这是一项单中心回顾性队列研究,研究对象为2008年至2013年期间在一家城市学术医疗中心48小时内发生的UIT,纳入年龄在18岁及以上且无预先指示(AD)的患者。关键干预措施通过改良德尔菲法定义。数据包括人口统计学、合并症、UIT原因、住院时间、CrI和死亡率。我们计算了95%置信区间(CI)的描述性统计数据。
在108732例从ED转入普通病房的患者中,共有837例(0.76%)在48小时内发生了UIT;86例入院患者在转入ICU之前死亡。我们排除了23份AD、117例术后转院、177例计划内ICU转院以及4例数据缺失的病例。在剩下的516例患者中,65%(95%CI,61%-69%)接受了CrI。非计划ICU转院的原因如下:33例医疗差错、90例入院时不存在的疾病过程以及393例临床病情恶化。有CrI的患者死亡率为10.5%(95%CI,8%-14%),平均住院时间为258小时(95%CI,233-283);而无CrI的患者死亡率为2.8%(95%CI,1%-6%),平均住院时间为177小时(95%CI,157-197)。
非计划ICU转院很少见,只有65%的患者有CrI。有CrI的患者发病率和死亡率更高。