用于细胞外pH检测的细胞表面锚定比率型i-基序传感器。
A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection.
作者信息
Ying Le, Xie Nuli, Yang Yanjing, Yang Xiaohai, Zhou Qifeng, Yin Bincheng, Huang Jin, Wang Kemin
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, China.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
出版信息
Chem Commun (Camb). 2016 Jun 14;52(50):7818-21. doi: 10.1039/c6cc03163c.
A FRET-based sensor is anchored on the cell surface through streptavidin-biotin interactions. Due to the excellent properties of the pH-sensitive i-motif structure, the sensor can detect extracellular pH with high sensitivity and excellent reversibility.
一种基于荧光共振能量转移（FRET）的传感器通过链霉亲和素-生物素相互作用锚定在细胞表面。由于pH敏感的i-基序结构具有优异的特性，该传感器能够以高灵敏度和出色的可逆性检测细胞外pH值。
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