Brudevold F, Bakhos Y, Aasenden R
J Am Dent Assoc. 1978 Mar;96(3):459-63. doi: 10.14219/jada.archive.1978.0097.
Rats (N = 58), given a diet low in fluoride, were stomach-fed solutions of NaF and (NH4)3AIF6 in amounts corresponding to 3.3, 8.3, and 16.5 microgram of fluoride per gram of body weight. After five weeks, the incisors were scored for fluorosis and samples of the incisors and mandibles were analyzed for fluoride. Less fluoride was deposited in teeth and bone from AIF6, than from NaF at all dosage levels. Less fluorosis also developed from AIF6, except at the lowest dosage level, which produced very little fluorosis in either group. Both incisor fluoride and fluorosis scores increased with increases in ingestion of fluoride. In a larger group of rats (N = 101) that had been on different fluoride regimens, the fluoride concentrations of the incisors were grouped according to the fluorosis scroes. There was a consistent trend of increase in fluoride with increase in fluorosis scores, but each score had a wide range and overlap in fluoride concentrations.
给58只大鼠喂食低氟饮食，通过胃饲法给予它们氟化钠（NaF）和六氟铝酸铵（(NH4)3AIF6）溶液，剂量相当于每克体重3.3、8.3和16.5微克氟。五周后，对大鼠的门齿进行氟中毒评分，并分析门齿和下颌骨样本中的氟含量。在所有剂量水平下，六氟铝酸铵组牙齿和骨骼中沉积的氟都比氟化钠组少。除了最低剂量水平（该剂量在两组中均产生极少的氟中毒）外，六氟铝酸铵组产生的氟中毒也较少。门齿中的氟含量和氟中毒评分均随氟摄入量的增加而升高。在另一组接受不同氟摄入方案的较大规模大鼠（N = 101）中，根据氟中毒评分对门齿的氟浓度进行分组。随着氟中毒评分的增加，氟含量呈现出持续上升的趋势，但每个评分对应的氟浓度范围都很广且有重叠。
