Tsoumtsa Landry L, Torre Cedric, Ghigo Eric
Centre National de la Recherche Scientifique UMR 7278, IRD198, Institut National de la Santé et de la Recherche Médicale U1095, Institut Hospitalier Universitaire Méditerranée-Infection, Aix-Marseille Université Marseille, France.
Front Cell Infect Microbiol. 2016 May 10;6:54. doi: 10.3389/fcimb.2016.00054. eCollection 2016.
Most of the biological functions, including the immune system, are linked to circadian rhythms in living organisms. Changes occurring to biological parameters as the result of these circadian rhythms can therefore affect the outcome of a disease. For decades, model organisms have proven to be a great tool to understanding biological mechanisms such as circadian cycle and immunity. In this review, we created an inventory of the use of model organisms in order to decipher the relation between circadian rhythms and antibacterial immunity.
包括免疫系统在内的大多数生物学功能都与生物体的昼夜节律相关联。因此，这些昼夜节律导致的生物学参数变化会影响疾病的转归。几十年来，模式生物已被证明是理解诸如昼夜节律和免疫等生物学机制的有力工具。在本综述中，我们梳理了模式生物的应用情况，以阐明昼夜节律与抗菌免疫之间的关系。
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