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Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.
J Am Chem Soc. 2016 Jun 15;138(23):7268-71. doi: 10.1021/jacs.6b03899. Epub 2016 May 31.
2
Investigations into an anionic oxy-cope/transannular conjugate addition approach to 7,20-diisocyanoadociane.
Org Lett. 2014 Sep 5;16(17):4368-71. doi: 10.1021/ol502205m. Epub 2014 Aug 8.
3
Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20-Diisocyanoadociane.
Angew Chem Int Ed Engl. 2019 Sep 23;58(39):13749-13752. doi: 10.1002/anie.201906834. Epub 2019 Aug 27.
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A formal total synthesis of the marine diterpenoid diisocyanoadociane.
Org Lett. 2006 Jul 20;8(15):3395-8. doi: 10.1021/ol061228f.
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Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids.
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Antiplasmodial activity: the first proof of inhibition of heme crystallization by marine isonitriles.
Eur J Med Chem. 2015 Mar 26;93:373-80. doi: 10.1016/j.ejmech.2015.02.011. Epub 2015 Feb 9.
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Antimalarial activity of azadipeptide nitriles.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):252-5. doi: 10.1016/j.bmcl.2009.10.122. Epub 2009 Oct 30.
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Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites.
Bioorg Med Chem. 2020 Oct 1;28(19):115678. doi: 10.1016/j.bmc.2020.115678. Epub 2020 Aug 1.

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The Paradox of Antimalarial Terpenoid Isonitrile Biosynthesis Explained. Proposal of Cyanoformate as an NC Delivery Vector.
J Nat Prod. 2025 Jan 24;88(1):205-210. doi: 10.1021/acs.jnatprod.4c01295. Epub 2024 Dec 20.
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Repositioning Brusatol as a Transmission Blocker of Malaria Parasites.
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3
A kalihinol analog disrupts apicoplast function and vesicular trafficking in malaria.
Science. 2024 Sep 27;385(6716):eadm7966. doi: 10.1126/science.adm7966.
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Heavy Heterodendralenes: Structure and Reactivity of Phosphabora[3]dendralenes.
J Am Chem Soc. 2024 Aug 28;146(34):23680-23685. doi: 10.1021/jacs.4c07850. Epub 2024 Aug 14.
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Unified Synthesis of 2-Isocyanoallopupukeanane and 9-Isocyanopupukeanane through a "Contra-biosynthetic" Rearrangement.
Angew Chem Int Ed Engl. 2024 Jan 22;63(4):e202317348. doi: 10.1002/anie.202317348. Epub 2023 Dec 20.
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An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure.
J Am Chem Soc. 2023 Feb 15;145(6):3716-3726. doi: 10.1021/jacs.2c13137. Epub 2023 Feb 2.
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Enantioselective oxa-Diels-Alder Sequences of Dendralenes.
Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202204872. doi: 10.1002/anie.202204872. Epub 2022 Aug 19.
9
Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane.
J Org Chem. 2022 Jan 21;87(2):1398-1420. doi: 10.1021/acs.joc.1c02700. Epub 2022 Jan 6.
10
Antimalarial Natural Products.
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本文引用的文献

1
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
ACS Infect Dis. 2016 Apr 8;2(4):281-293. doi: 10.1021/acsinfecdis.5b00143. Epub 2016 Feb 10.
2
A Formal Enantiospecific Synthesis of 7,20-Diisocyanoadociane.
Angew Chem Int Ed Engl. 2016 Jun 13;55(25):7180-3. doi: 10.1002/anie.201603581. Epub 2016 May 10.
3
Ph(i-PrO)SiH2: An Exceptional Reductant for Metal-Catalyzed Hydrogen Atom Transfers.
J Am Chem Soc. 2016 Apr 13;138(14):4962-71. doi: 10.1021/jacs.6b02032. Epub 2016 Mar 30.
4
Marine Isonitriles and Their Related Compounds.
Mar Drugs. 2016 Jan 14;14(1):16. doi: 10.3390/md14010016.
5
A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad Actors.
Chem Rev. 2015 Sep 9;115(17):9465-531. doi: 10.1021/acs.chemrev.5b00154. Epub 2015 Jul 9.
6
Synthesis and potent antimalarial activity of kalihinol B.
J Am Chem Soc. 2015 Apr 22;137(15):4912-5. doi: 10.1021/jacs.5b01152. Epub 2015 Apr 9.
7
Antiplasmodial activity: the first proof of inhibition of heme crystallization by marine isonitriles.
Eur J Med Chem. 2015 Mar 26;93:373-80. doi: 10.1016/j.ejmech.2015.02.011. Epub 2015 Feb 9.
8
Pseudopterosin synthesis from a chiral cross-conjugated hydrocarbon through a series of cycloadditions.
Nat Chem. 2015 Jan;7(1):82-6. doi: 10.1038/nchem.2112. Epub 2014 Nov 17.
9
Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.
Nat Prod Rep. 2015 Apr;32(4):543-77. doi: 10.1039/c4np00109e.
10
Investigations into an anionic oxy-cope/transannular conjugate addition approach to 7,20-diisocyanoadociane.
Org Lett. 2014 Sep 5;16(17):4368-71. doi: 10.1021/ol502205m. Epub 2014 Aug 8.

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