Schnermann Martin J, Shenvi Ryan A
Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21701, USA.
Nat Prod Rep. 2015 Apr;32(4):543-77. doi: 10.1039/c4np00109e.
Isocyanoterpenes (ICTs) are marine natural products biosynthesized through an unusual pathway that adorns terpene scaffolds with nitrogenous functionality derived from cyanide. The appendage of nitrogen functional groups - isonitriles in particular - onto stereochemically-rich carbocyclic ring systems provides enigmatic, bioactive molecules that have required innovative chemical syntheses. This review discusses the challenges inherent to the synthesis of this diverse family and details the development of the field. We also present recent progress in isolation and discuss key aspects of the remarkable biological activity of these compounds.
异氰基萜类化合物（ICTs）是通过一种不同寻常的途径生物合成的海洋天然产物，该途径用源自氰化物的含氮官能团修饰萜类骨架。特别是将氮官能团（尤其是异腈）连接到立体化学丰富的碳环系统上，会产生具有神秘生物活性的分子，这些分子需要创新的化学合成方法。本综述讨论了合成这个多样化家族所固有的挑战，并详细介绍了该领域的发展情况。我们还介绍了分离方面的最新进展，并讨论了这些化合物显著生物活性的关键方面。
