Wang Zhi-fei, Ai Qing-hua, Li Yuan-yuan, Jiang Jun-jie, Wang Lian-xin, Yang Wei, Xie Yan-ming
Zhongguo Zhong Yao Za Zhi. 2015 Dec;40(24):4762-5.
The purpose of the study is to find the allergic reaction types and characteristics of Chinese medicine injection ( CMI). The authors monitored patients who used Shuxuetong injection, Dengzhan Xixin injection, Shenqi Fuzheng injection, Shenmai injection, Ciwujia injection, Shuxuening injection, Tanreqing injection, Reduning injection, a total of 150,000 cases were monitored. They used a nested case-control design to group the patients and obtained the serum samples from 14 allergic patients and 55 matched patients. They used enzyme-linked immunosorbent assay (ELISA) to detect serum C3, C4, IgE, IgG, MCT-P, and judge the allergic reaction types: Shuxuetong injection hypersensitivity (1 case), can not determine (1 case); Dengzhan Xixin injection hypersensitivity (1 case), hypersensitivity & anaphylactoid reaction (1 case), can not determine (1 case); Shenqi Fuzheng injection hypersensitivity (3 cases), can not determine (1 case); Shenmai injection anaphylactoid reaction (1 case); Ciwujia injection can not determine (1 case), Shuxuening injection can not determine (1 case), Tanreqing injection can not determine (1 case), Reduning injection can not determine (1 case). The results showed that the main type of allergic reaction of CMI was hypersensitivity, the type of allergic reaction was closely related to the varieties of CMI, the hypersensitivity and anaphylactoid reaction might occur in one patient at the same time which used Dengzhan Xixin injection.
本研究旨在探讨中药注射剂（CMI）的过敏反应类型及特点。作者对使用舒血宁注射液、灯盏细辛注射液、参芪扶正注射液、参麦注射液、刺五加注射液、舒血宁注射液、痰热清注射液、热毒宁注射液的患者进行监测，共监测15万例。采用巢式病例对照设计对患者进行分组，并采集了14例过敏患者和55例匹配患者的血清样本。采用酶联免疫吸附测定法（ELISA）检测血清C3、C4、IgE、IgG、MCT - P，并判断过敏反应类型：舒血宁注射液过敏（1例），无法确定（1例）；灯盏细辛注射液过敏（1例），过敏及类过敏反应（1例），无法确定（1例）；参芪扶正注射液过敏（3例），无法确定（1例）；参麦注射液类过敏反应（1例）；刺五加注射液无法确定（1例），舒血宁注射液无法确定（1例），痰热清注射液无法确定（1例），热毒宁注射液无法确定（1例）。结果显示，CMI过敏反应的主要类型为过敏，过敏反应类型与CMI品种密切相关，使用灯盏细辛注射液的患者可能同时出现过敏及类过敏反应。
