Matsui Y, Yamagami I, Iwata N
Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Jpn J Pharmacol. 1989 Jan;49(1):119-24. doi: 10.1254/jjp.49.119.
Effects of S-adenosyl-L-methionine on Ca accumulation as well as the changes of electrolytes contents and glucose metabolism after transient ischemia were investigated. In the 4-vessel occlusion model of rats, brain Ca content increased to 200-250% of that in sham operated rats 1 day after 60 min transient ischemia. The change in the striatum was more severe than that in the cortex or hippocampus. Na content increased and K content decreased, and glucose, pyruvate and lactate contents increased significantly in the striatum 1 day after transient ischemia. SAM (100 mg/kg, i.p.) was injected at the end of occlusion and every hour for 5 hr thereafter. Treatment with SAM reduced Ca accumulation, decrease of K, and increase of lactate and pyruvate in the striatum significantly. The present results suggest that the inhibition of Ca accumulation might partly explain the beneficial effects of SAM on the cerebral dysfunction following ischemia.
研究了S-腺苷-L-蛋氨酸对短暂性脑缺血后钙蓄积以及电解质含量和葡萄糖代谢变化的影响。在大鼠四动脉闭塞模型中，短暂性脑缺血60分钟后1天，脑钙含量增加至假手术大鼠的200%-250%。纹状体的变化比皮质或海马体更严重。短暂性脑缺血后1天，纹状体内钠含量增加，钾含量降低，葡萄糖、丙酮酸和乳酸含量显著增加。在闭塞结束时腹腔注射SAM（100mg/kg），并在随后的5小时内每小时注射一次。SAM治疗可显著减少纹状体内钙蓄积、钾减少以及乳酸和丙酮酸增加。目前的结果表明，抑制钙蓄积可能部分解释了SAM对缺血后脑功能障碍的有益作用。
