文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Otero-Losada M E, Rubio M C

Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Cientificas y Técnicas, Piso, Buenos Aires, Argentina.

Gen Pharmacol. 1989;20(4):403-6. doi: 10.1016/0306-3623(89)90186-9.

This study investigates S-adenosyl-L-methionine (SAM) (10 mg/kg, i.p.)acute effects upon 5-HT metabolism in rat brain areas. 2. One hour after SAM injection 5-HT biosynthesis was increased in the corpus striatum (55%), the hippocampus (3-fold) (82% 2 hr after SAM injection) and decreased in the olfactory bulbs (34%). 3. 5-HT levels were: (a) increased in the corpus striatum (39%), the hippocampus (44%) and the frontal cortex (27%), and oppositely reduced in the olfactory bulbs (47%) 1 hr after SAM injection; (b) increased in the hippocampus (39%) and reduced in the olfactory bulbs (35%) 1.5 hr after SAM injection; (c) increased in the hippocampus (25%) 2 hr after SAM injection. 4. 5-HIAA levels were reduced in the olfactory bulbs 27% or 21% after 1 hr or 1.5 hr from SAM injection respectively. 5. These area-related changes in 5-HT biosynthesis and metabolism might suggest a possible neurochemical substrate for the antidepressant properties of SAM.

本研究调查了S-腺苷-L-甲硫氨酸（SAM）（10毫克/千克，腹腔注射）对大鼠脑区5-羟色胺（5-HT）代谢的急性影响。2. SAM注射1小时后，纹状体中5-HT生物合成增加（55%），海马体中增加3倍（SAM注射2小时后增加82%），嗅球中减少（34%）。3. 5-HT水平如下：（a）SAM注射1小时后，纹状体中增加（39%），海马体中增加（44%），额叶皮质中增加（27%），嗅球中则相反减少（47%）；（b）SAM注射1.5小时后，海马体中增加（39%），嗅球中减少（35%）；（c）SAM注射2小时后，海马体中增加（25%）。4. SAM注射1小时或1.5小时后，嗅球中5-羟吲哚乙酸（5-HIAA）水平分别降低27%或21%。5. 5-HT生物合成和代谢中这些与脑区相关的变化可能提示SAM抗抑郁特性的一种潜在神经化学底物。

Otero-Losada M E, Rubio M C

Instituto de Investigaciones Farmacológicas, Consejo Nacional de Investigaciones Cientificas y Técnicas, Piso, Buenos Aires, Argentina.

Gen Pharmacol. 1989;20(4):403-6. doi: 10.1016/0306-3623(89)90186-9.

This study investigates S-adenosyl-L-methionine (SAM) (10 mg/kg, i.p.)acute effects upon 5-HT metabolism in rat brain areas. 2. One hour after SAM injection 5-HT biosynthesis was increased in the corpus striatum (55%), the hippocampus (3-fold) (82% 2 hr after SAM injection) and decreased in the olfactory bulbs (34%). 3. 5-HT levels were: (a) increased in the corpus striatum (39%), the hippocampus (44%) and the frontal cortex (27%), and oppositely reduced in the olfactory bulbs (47%) 1 hr after SAM injection; (b) increased in the hippocampus (39%) and reduced in the olfactory bulbs (35%) 1.5 hr after SAM injection; (c) increased in the hippocampus (25%) 2 hr after SAM injection. 4. 5-HIAA levels were reduced in the olfactory bulbs 27% or 21% after 1 hr or 1.5 hr from SAM injection respectively. 5. These area-related changes in 5-HT biosynthesis and metabolism might suggest a possible neurochemical substrate for the antidepressant properties of SAM.

本研究调查了S-腺苷-L-甲硫氨酸（SAM）（10毫克/千克，腹腔注射）对大鼠脑区5-羟色胺（5-HT）代谢的急性影响。2. SAM注射1小时后，纹状体中5-HT生物合成增加（55%），海马体中增加3倍（SAM注射2小时后增加82%），嗅球中减少（34%）。3. 5-HT水平如下：（a）SAM注射1小时后，纹状体中增加（39%），海马体中增加（44%），额叶皮质中增加（27%），嗅球中则相反减少（47%）；（b）SAM注射1.5小时后，海马体中增加（39%），嗅球中减少（35%）；（c）SAM注射2小时后，海马体中增加（25%）。4. SAM注射1小时或1.5小时后，嗅球中5-羟吲哚乙酸（5-HIAA）水平分别降低27%或21%。5. 5-HT生物合成和代谢中这些与脑区相关的变化可能提示SAM抗抑郁特性的一种潜在神经化学底物。