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Paf15的表达与直肠癌的预后、细胞增殖及放射反应相关。

Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response.

作者信息

Yan Rong, Zhu Kun, Dang Chengxue, Lan Ke, Wang Haonan, Yuan Dawei, Chen Wei, Meltzer Stephen J, Li Kang

机构信息

Department of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China.

Department of Medicine (GI Division) and Oncology, Johns Hopkins School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

出版信息

Oncotarget. 2016 Jun 21;7(25):38750-38761. doi: 10.18632/oncotarget.9606.

DOI:10.18632/oncotarget.9606
PMID:27246972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5122426/
Abstract

Paf15, which participates in DNA repair, is overexpressed in numerous solid tumors. Blocking of Paf15 inhibits the growth of many types of cancer cells; while simultaneously enhancing cellular sensitivity to UV radiation. However, its expression and function in rectal cancer (RC) remain unknown. The current study was undertaken to assess the association of Paf15 expression with RC prognosis, as well as to explore the participation of Paf15 in the response of RC cells to irradiation. Increased Paf15 expression was observed in RC tissues and associated with pTNM stage and poor survival. In vitro, Paf15 induced increased RC cell proliferation while accelerating cell cycle progression, inhibiting cell death, and protecting against gamma radiation-induced DNA damage in RC cells. In conclusion, increased Paf15 expression is associated with increased RC proliferation, decreased patient survival, and a worse radiotherapeutic response.

摘要

参与DNA修复的Paf15在众多实体瘤中过表达。阻断Paf15可抑制多种癌细胞的生长；同时增强细胞对紫外线辐射的敏感性。然而，其在直肠癌（RC）中的表达和功能仍不清楚。本研究旨在评估Paf15表达与RC预后的关联，并探讨Paf15在RC细胞对辐射反应中的作用。在RC组织中观察到Paf15表达增加，且与pTNM分期及不良生存相关。在体外，Paf15可诱导RC细胞增殖增加，同时加速细胞周期进程，抑制细胞死亡，并保护RC细胞免受γ射线诱导的DNA损伤。总之，Paf15表达增加与RC增殖增加、患者生存率降低及放疗反应较差有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/72b50ad4f079/oncotarget-07-38750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/dcda7831dba6/oncotarget-07-38750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/97da2d23eba7/oncotarget-07-38750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/b02176eaa159/oncotarget-07-38750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/07f299e2f74b/oncotarget-07-38750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/c1fa9b436ad5/oncotarget-07-38750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/72b50ad4f079/oncotarget-07-38750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/dcda7831dba6/oncotarget-07-38750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/97da2d23eba7/oncotarget-07-38750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/b02176eaa159/oncotarget-07-38750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/07f299e2f74b/oncotarget-07-38750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/c1fa9b436ad5/oncotarget-07-38750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edf/5122426/72b50ad4f079/oncotarget-07-38750-g006.jpg

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1
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J Biol Res (Thessalon). 2014 Aug 1;21(1):14. doi: 10.1186/2241-5793-21-14. eCollection 2014 Dec.
2
Inflammatory Bowel Disease-related Colorectal Cancer in the Asia-Pacific Region: Past, Present, and Future.亚太地区炎症性肠病相关结直肠癌：过去、现在与未来
Intest Res. 2014 Jul;12(3):194-204. doi: 10.5217/ir.2014.12.3.194. Epub 2014 Jul 25.
3
Expression of KIAA0101 protein is associated with poor survival of esophageal cancer patients and resistance to cisplatin treatment in vitro.
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Int J Mol Sci. 2022 May 27;23(11):6040. doi: 10.3390/ijms23116040.
4
PCNA-associated factor KIAA0101 transcriptionally induced by ELK1 controls cell proliferation and apoptosis in nasopharyngeal carcinoma: an integrated bioinformatics and experimental study.ELK1 转录诱导的 PCNA 相关因子 KIAA0101 调控鼻咽癌细胞增殖和凋亡：一项整合生物信息学和实验研究。
Aging (Albany NY). 2020 Apr 9;12(7):5992-6017. doi: 10.18632/aging.102991.
5
Non-operative management of rectal cancer: understanding tumor biology.直肠癌的非手术治疗：了解肿瘤生物学
Minerva Chir. 2018 Dec;73(6):601-618. doi: 10.23736/S0026-4733.18.07743-X. Epub 2018 May 24.
6
Prognosis and value of preoperative radiotherapy in locally advanced rectal signet-ring cell carcinoma.局部进展期直肠印戒细胞癌术前放疗的预后及价值。
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7
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Int J Mol Sci. 2017 Mar 7;18(3):573. doi: 10.3390/ijms18030573.
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