乙型、丙型和丁型肝炎病毒感染在注射吸毒者和普通人群中呈现出不同模式。

Hepatitis B, C, and D virus infection showing distinct patterns between injection drug users and the general population.

作者信息

Chen Fei, Zhang Jian, Guo Fengfan, Wen Bo, Luo Shan, Yuan Dongping, Lin Yingbiao, Ou Wensheng, Tang Ping, Dai Guozhi, Li Fangfang, Liu Wenpei, Qu Xiaowang

机构信息

Translational Medicine Institute, National and Local Joint Engineering Laboratory for High-throughput Molecular Diagnosis Technology, Affiliated The First People's Hospital of Chenzhou, University of South China, Chenzhou, China.

The Fourth People's Hospital of Changde, Hunan province, China.

出版信息

J Gastroenterol Hepatol. 2017 Feb;32(2):515-520. doi: 10.1111/jgh.13460.

DOI:10.1111/jgh.13460

PMID:27248508

Abstract

BACKGROUND AND AIM

Hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are known to be prevalent in injection drug users (IDUs); however, the relationship between the molecular epidemiologic features of hepatitis virus infection in high-risk individuals and the general population has not yet been established.

METHODS

In total, 1049 IDUs and 672 individuals who underwent physical examinations at Chenzhou hospital, Hunan Province, China, were enrolled. HBV, HCV, and HDV infections were screened with serologic tests in both populations. HBsAg-positive, anti-HCV IgG-positive, and anti-HDV IgG-positive samples were further confirmed by polymerase chain reaction, quantitative polymerase chain reaction, and DNA sequencing.

RESULTS

Significantly higher HBV (21.54 vs 16.52%, P = 0.01), HCV (45.95% vs 1.34%, P < 0.001), and HDV (5.62% vs 0.30%, P < 0.001) infections were detected in IDUs compared with the general population. The dual infection of HBV/HCV or HBV/HDV was also significantly higher in IDUs than in the general population. HBV genotype B and HDV genotype II were dominants in both populations. HCV infection showed genotype 6a (49.52%) dominant in IDUs, but genotype 1b accounted for 50% infection, which was followed by genotype 6a (33.33%) in the general population. Higher viral loads were associated with HBV genotype B and HCV genotype 6a compared with non-dominant genotypic infections.

CONCLUSIONS

HBV and HDV infections shared similar patterns by IDUs and the general populations, and HCV infection exhibited distinct features between two populations. Our results suggest different molecular epidemiologic characteristics of HBV, HCV, and HDV infection in two populations.

摘要

背景与目的

已知乙型、丙型和丁型肝炎病毒（HBV、HCV和HDV）感染在注射吸毒者（IDU）中普遍存在；然而，高危个体与普通人群中肝炎病毒感染的分子流行病学特征之间的关系尚未确立。

方法

共纳入了1049名注射吸毒者和672名在中国湖南省郴州市医院接受体检的个体。对这两个人群均采用血清学检测筛查HBV、HCV和HDV感染。对HBsAg阳性、抗-HCV IgG阳性和抗-HDV IgG阳性样本进一步通过聚合酶链反应、定量聚合酶链反应和DNA测序进行确认。

结果

与普通人群相比，在注射吸毒者中检测到的HBV（21.54%对16.52%，P = 0.01）、HCV（45.95%对1.34%，P < 0.001）和HDV（5.62%对0.30%，P < 0.001）感染显著更高。HBV/HCV或HBV/HDV的双重感染在注射吸毒者中也显著高于普通人群。HBV基因型B和HDV基因型II在两个人群中均占主导。HCV感染在注射吸毒者中显示基因型6a占主导（49.52%），但在普通人群中基因型1b占感染的50%，其次是基因型6a（33.33%）。与非主导基因型感染相比，较高的病毒载量与HBV基因型B和HCV基因型6a相关。