治疗皮肤红斑狼疮的选择：最新进展和未来前景。
Therapeutic options for cutaneous lupus erythematosus: recent advances and future prospects.
机构信息
a Dermatology Section, Corporal Michael J. Crescenz Philadelphia VA Medical Center , Philadelphia , PA , USA.
b Department of Dermatology , Perelman School of Medicine at the University of Pennsylvania , Philadelphia , PA , USA.
出版信息
Expert Rev Clin Immunol. 2016 Oct;12(10):1109-21. doi: 10.1080/1744666X.2016.1188006. Epub 2016 Jun 1.
Abstract
INTRODUCTION
Treatment and prevention are of critical importance in patients with cutaneous lupus erythematosus (CLE), as the disease can have a devastating effect on patient well-being and quality of life.
AREAS COVERED
We conducted a selective search of the PubMed database for articles published between December 2010 and November 2015. This review encompasses both non-pharmaceutical (photoprotection, smoking cessation, drug withdrawal, and vitamin D replacement) and pharmaceutical (topicals, antimalarials, immunosuppressives, biologics, etc.) interventions used in the treatment of CLE. Expert Commentary: Recent work has expanded our understanding of established therapies as well as introduced new treatments for consideration, though existing medications still prove inadequate for a subset of patients. Changes in trial design may help to alleviate this issue.
摘要
简介
在患有红斑狼疮（CLE）的患者中，治疗和预防至关重要，因为该疾病会严重影响患者的健康和生活质量。
涵盖领域
我们对 2010 年 12 月至 2015 年 11 月期间发表的文章进行了有选择性的 PubMed 数据库检索。本综述涵盖了非药物（光保护、戒烟、药物停用和维生素 D 替代）和药物（局部制剂、抗疟药、免疫抑制剂、生物制剂等）干预治疗 CLE 的应用。专家评论：最近的研究工作加深了我们对既定疗法的理解，同时也引入了新的治疗方法供考虑，尽管现有药物对某些患者仍不够理想。临床试验设计的改变可能有助于缓解这个问题。
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