Raphemot Rene, Posfai Dora, Derbyshire Emily R
J Clin Invest. 2016 Jun 1;126(6):2013-20. doi: 10.1172/JCI82981.
Malaria remains a global public health threat, with half of the world's population at risk. Despite numerous efforts in the past decade to develop new antimalarial drugs to surmount increasing resistance to common therapies, challenges remain in the expansion of the current antimalarial arsenal for the elimination of this disease. The requirement of prophylactic and radical cure activities for the next generation of antimalarial drugs demands that new research models be developed to support the investigation of the elusive liver stage of the malaria parasite. In this Review, we revisit current antimalarial therapies and discuss recent advances for in vitro and in vivo malaria research models of the liver stage and their importance in probing parasite biology and the discovery of novel drug candidates.
疟疾仍然是全球公共卫生威胁，全球一半人口面临风险。尽管在过去十年中为开发新的抗疟药物做出了诸多努力，以克服对常见疗法日益增加的耐药性，但在扩充当前抗疟药物库以消除这种疾病方面仍存在挑战。下一代抗疟药物对预防和根治的要求，需要开发新的研究模型来支持对难以捉摸的疟原虫肝期的研究。在本综述中，我们回顾了当前的抗疟疗法，并讨论了肝期疟疾体外和体内研究模型的最新进展，以及它们在探究寄生虫生物学和发现新型候选药物方面的重要性。
