Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Department of Chemistry, Duke University, Durham, NC, USA.
Trends Parasitol. 2022 Jul;38(7):544-557. doi: 10.1016/j.pt.2022.04.004. Epub 2022 May 6.
Plasmodium parasites extensively alter their host hepatocyte to evade host detection and support an unprecedented replication rate. Host cell manipulation includes association with the host early and late endomembrane systems, where Plasmodium accesses nutrients while suppressing cellular immune processes. Early endomembrane organelles provide an opportunity to sequester an abundance of lipids and proteins, but the association with late endomembrane organelles also risks autophagy-mediated elimination. While not all parasites survive, those that do benefit from a plethora of nutrients provided through this pathway. In this review, we discuss recent advances in our understanding of how Plasmodium parasites balance the need for host nutrients while avoiding elimination during the liver stage.
疟原虫广泛改变其宿主肝细胞以逃避宿主检测并支持前所未有的复制率。宿主细胞操纵包括与宿主早期和晚期内体系统的关联，疟原虫在抑制细胞免疫过程的同时获取营养。早期内体细胞器提供了隔离大量脂质和蛋白质的机会，但与晚期内体细胞器的关联也有被自噬介导消除的风险。虽然并非所有寄生虫都能存活下来，但那些存活下来的寄生虫受益于通过这条途径提供的大量营养。在这篇综述中，我们讨论了我们对疟原虫寄生虫如何平衡对宿主营养的需求与在肝脏阶段避免消除之间的理解的最新进展。
