Frolkis V V, Martynenko O A, Timchenko A N
Institute of Gerontology, AMS USSR, Kiev, U.S.S.R.
Mech Ageing Dev. 1989 Jan;47(1):47-54. doi: 10.1016/0047-6374(89)90006-7.
The function of the membrane potassium channels of the identified neurons of the small parietal ganglion was investigated in the adult (10-12-month) and old (22-24-month) molluscs Lymnaea stagnalis. Old molluscan neurons showed a decrease in maximal amplitude of fast and delayed potassium currents, in maximal potassium conductance, and in kinetics of inactivation of the delayed outward current. These features may be conditioned by the age changes in phospholipid composition of the membranes, rather than by the shifts of neuronal surface area during aging. Age dynamics in the function of potassium channels is thought to cause changes in the neuronal function.
在成年（10 - 12个月）和老年（22 - 24个月）的椎实螺（Lymnaea stagnalis）中，研究了小型顶神经节中已识别神经元的膜钾通道功能。老年软体动物神经元的快速和延迟钾电流的最大幅度、最大钾电导以及延迟外向电流的失活动力学均有所下降。这些特征可能是由膜磷脂组成的年龄变化所决定，而非衰老过程中神经元表面积的变化。钾通道功能的年龄动态变化被认为会导致神经元功能的改变。
