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[牛磺酸对池塘蜗牛神经元体膜电控离子通道的影响]

[The effect of taurine on the electrically controlled ion channels of the somatic membrane of pond snail neurons].

作者信息

Vislobokov A I, Mantsev V V, Kopylov A G, Gurevich V S

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1991 Feb;77(2):37-42.

PMID:1715296
Abstract

Isolated and internally dialysed neurons from the molluscs Lymnaea stagnalis were investigated under voltage-clamp conditions. The increasing of taurin concentration (from 1.10(-8) to 1.10(-2) mol/l) reduced the calcium inward--and delayed potassium outward currents, and exerted no effect on the fast potassium outward current. Sodium inward current was increased by taurin concentrations 1.10(-8)-1.10(-4) mol/l, and reduced by 1.10(-3)-1.10(-2) mol/l. Membrane leakage currents were reduced by small taurin concentrations and increased by large concentrations.

摘要

在电压钳制条件下,对来自椎实螺的分离并经内部透析的神经元进行了研究。牛磺酸浓度增加(从1×10⁻⁸到1×10⁻²mol/L)会降低内向钙电流和延迟外向钾电流,而对快速外向钾电流没有影响。浓度为1×10⁻⁸ - 1×10⁻⁴mol/L的牛磺酸会增加内向钠电流,而浓度为1×10⁻³ - 1×10⁻²mol/L时则会降低内向钠电流。低浓度牛磺酸会降低膜漏电流,高浓度则会增加膜漏电流。

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