Taylor Caroline M, Golding Jean, Emond Alan M
Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Centre for Child and Adolescent Health, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Int J Hyg Environ Health. 2016 Aug;219(6):513-20. doi: 10.1016/j.ijheh.2016.05.004. Epub 2016 May 18.
To avoid exposure to mercury, government advice on fish consumption during pregnancy includes information on fish species to avoid and to limit, while encouraging consumption of least two portions of fish per week. Some women may, however, chose to avoid fish completely during pregnancy despite potential benefits to the fetus.
Our aims were to evaluate the effects of blood mercury levels in pregnant women on birth outcomes in the UK, and to compare outcomes in those who ate fish with those who did not.
Pregnant women were enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood samples for singleton pregnancies with a live birth were analysed for Hg by inductively coupled plasma dynamic reaction cell mass spectrometry (n=4044). Fish intake was determined by a food frequency questionnaire during pregnancy. Data collected on the infants included anthropometric variables and gestational age at delivery. Regression models were adjusted for covariates using SPSS v23.
There were no significant associations of maternal blood Hg level with birthweight, head circumference or crown-heel length in adjusted linear regression models. Similarly, there were no increased odds of low birthweight or preterm delivery in adjusted logistic regression models. When the models were repeated after stratification into fish-eaters and there were no associations except for a negative association with birthweight in non-fish-eaters (unstandardised B coefficient -58.4 (95% confidence interval -113.8, -3.0) g, p=0.039).
Moderate mercury levels in pregnancy were not associated with anthropometric variables, or on the odds of low birthweight or preterm birth. Fish consumption may have a protective effect on birthweight. Consumption of fish in line with government guidelines during pregnancy should be encouraged.
为避免接触汞，政府关于孕期鱼类消费的建议包括应避免和限制食用的鱼类品种信息，同时鼓励每周至少食用两份鱼。然而，一些女性可能在孕期完全不吃鱼，尽管吃鱼对胎儿可能有益。
我们的目的是评估英国孕妇血液汞水平对出生结局的影响，并比较吃鱼和不吃鱼的孕妇的结局。
孕妇参加了埃文亲子纵向研究（ALSPAC）。采用电感耦合等离子体动态反应池质谱法对单胎活产孕妇的全血样本进行汞分析（n = 4044）。通过孕期食物频率问卷确定鱼类摄入量。收集的婴儿数据包括人体测量变量和分娩时的孕周。使用SPSS v23对协变量进行回归模型调整。
在调整后的线性回归模型中，母亲血液汞水平与出生体重、头围或顶臀长度之间无显著关联。同样，在调整后的逻辑回归模型中，低出生体重或早产的几率也没有增加。将模型分层为吃鱼者和不吃鱼者后重复分析，除了不吃鱼者中与出生体重呈负相关外，没有其他关联（未标准化B系数为-58.4（95%置信区间-113.8，-3.0）g，p = 0.039）。
孕期汞水平适中与人体测量变量无关，也与低出生体重或早产的几率无关。吃鱼可能对出生体重有保护作用。应鼓励孕妇按照政府指南食用鱼类。
