Aringer M, Dörner T, Leuchten N, Johnson S R
Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany
Department of Medicine, Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin & DRFZ Berlin, Berlin, Germany.
Lupus. 2016 Jul;25(8):805-11. doi: 10.1177/0961203316644338.
While clearly different in their aims and means, classification and diagnosis both try to accurately label the disease patients are suffering from. For systemic lupus erythematosus (SLE), this is complicated by the multi-organ nature of the disease and by our incomplete understanding of its pathophysiology. Hallmarks of SLE are the presence of antinuclear antibodies (ANA), and multiple immune-mediated organ symptoms that are largely independent. In an attempt to overcome limitations of the current sets of SLE classification criteria, a new four-phase approach is being developed, which is jointly supported by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). This review attempts to delineate the performance of the current sets of criteria, the reasons for the decision for classification, and not diagnostic, criteria, and to provide a background of the current approach taken.
虽然分类和诊断在目的和方法上明显不同，但二者都试图准确标记出患者所患的疾病。对于系统性红斑狼疮（SLE）而言，由于该疾病的多器官性质以及我们对其病理生理学的不完全理解，这一过程变得复杂。SLE的特征是存在抗核抗体（ANA）以及多种基本独立的免疫介导器官症状。为了克服当前SLE分类标准集的局限性，一种新的四阶段方法正在研发中，该方法得到了欧洲抗风湿病联盟（EULAR）和美国风湿病学会（ACR）的联合支持。本综述试图阐述当前标准集的性能、采用分类而非诊断标准的原因，并提供当前所采用方法的背景信息。
