Prochaska Erica C, Sciallis Andrew P, Miller Barbra S
Medical School, University of Michigan, Ann Arbor, MI, USA.
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
J Surg Case Rep. 2016 Jun 1;2016(6):rjw049. doi: 10.1093/jscr/rjw049.
Establishing the etiology of a retroperitoneal tumor may be difficult due to close proximity of multiple organs. Evaluation of retroperitoneal tumors often leads to surgery, many times to obtain a definitive diagnosis and rule out malignancy. Calcifying fibrous tumors (CFT) are very rare soft tissue tumors occurring most often in young patients. They are most often found arising in the thoracic cavity, mediastinum, abdominal cavity and extremities and usually have a benign clinical course. Macrocscopically, the tumors are well circumscribed and firm with a white-tan appearance. Histologically, CFT comprised a hypocellular proliferation of bland spindle cells, densely hyalinized collagen, chronic lymphoplasmacytic inflammation and dystrophic calcifications. Other considerations in the pathologic differential diagnosis include solitary fibrous tumor and inflammatory myofibroblastic tumor.
由于多个器官位置相邻，确定腹膜后肿瘤的病因可能很困难。对腹膜后肿瘤的评估通常会导致手术，很多时候是为了获得明确诊断并排除恶性肿瘤。钙化性纤维瘤（CFT）是非常罕见的软组织肿瘤，最常发生于年轻患者。它们最常出现在胸腔、纵隔、腹腔和四肢，通常具有良性临床病程。大体上，肿瘤边界清楚、质地坚实，呈灰白色。组织学上，CFT由温和的梭形细胞、密集玻璃样变的胶原、慢性淋巴细胞浆细胞性炎症和营养不良性钙化组成的细胞减少性增生构成。病理鉴别诊断中的其他考虑因素包括孤立性纤维瘤和炎性肌纤维母细胞瘤。
