Fetsch J F, Montgomery E A, Meis J M
Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, D.C. 2306-6000.
Am J Surg Pathol. 1993 May;17(5):502-8. doi: 10.1097/00000478-199305000-00010.
We report 10 cases of a distinctive benign fibrous lesion characterized by the presence of abundant hyalinized collagen with psammomatous or dystrophic calcifications and a lymphoplasmacytic infiltrate. The lesions were present from 2 months to 10 years before resection and ranged in size from 2.5 to 15 cm. They involved subcutaneous and deep soft tissues and, although relatively well-circumscribed, occasionally infiltrative borders or entrapped structures were seen on microscopic examination. The lesions were located in the extremities (three cases), trunk (two cases), scrotum (two cases), groin (one case), neck (one case), and axilla (one case). Both sexes were equally affected. The mean and median ages of the patients were 16.2 and 18.5 years, respectively (range, 1 to 33 years). All cases were initially managed by simple local excision. Follow-up ranging from 2 months to more than 10 years (median, 41.5 months) was available in six cases and revealed a local recurrence in one instance; this became clinically apparent about 7.5 years after the initial resection. Morphologic features and follow-up data suggest this may be a unique form of fibrous pseudotumor.
我们报告了10例独特的良性纤维性病变，其特征为存在大量玻璃样变的胶原，伴有砂粒体样或营养不良性钙化以及淋巴细胞和浆细胞浸润。这些病变在切除前存在2个月至10年，大小从2.5厘米至15厘米不等。它们累及皮下和深部软组织，尽管边界相对清晰，但在显微镜检查时偶尔可见浸润性边界或包绕的结构。病变位于四肢（3例）、躯干（2例）、阴囊（2例）、腹股沟（1例）、颈部（1例）和腋窝（1例）。男女受累情况相同。患者的平均年龄和中位年龄分别为16.2岁和18.5岁（范围为1至33岁）。所有病例最初均采用单纯局部切除治疗。6例患者有2个月至10年以上（中位时间为41.5个月）的随访，其中1例出现局部复发；这在初次切除后约7.5年临床上变得明显。形态学特征和随访数据表明，这可能是一种独特形式的纤维性假瘤。
