De Boer S, Mirmiran M, Van Haaren F, Louwerse A, van de Poll N E
Netherlands Institute of Brain Research, Amsterdam.
Neurotoxicol Teratol. 1989 Jan-Feb;11(1):77-84. doi: 10.1016/0892-0362(89)90089-5.
Neonatal treatment of rats with centrally acting drugs such as clomipramine was shown to affect adult body and brain weight, behavior and sleep. We made a further study of the effects of clomipramine and tested one dose of alpha-methyldopa. Male rats were treated twice daily with saline, 7.5 or 15 mg/kg clomipramine or 100 mg/kg alpha-methyldopa from postnatal day 2-14 and tested in adulthood for effects on acquisition of radial maze behavior, on problem solving behavior in Hebb-Williams mazes, sexual performance and sleep-wake patterns. Clomipramine-treated rats had reduced body weight. No effects of neonatal drug treatment were found on several measures in the two mazes. Ejaculating rats in all three treatment groups showed longer latencies for sexual behavior and clomipramine-treated rats showed fewer ejaculations. Clomipramine-treated rats spent more time sleeping than the controls during the 24 hr sleep-wake recordings in adulthood.
用氯米帕明等中枢作用药物对新生大鼠进行治疗，已表明会影响成年大鼠的体重、脑重、行为和睡眠。我们对氯米帕明的作用进行了进一步研究，并测试了一剂α-甲基多巴。从出生后第2天至第14天，每天两次用生理盐水、7.5或15毫克/千克氯米帕明或100毫克/千克α-甲基多巴对雄性大鼠进行治疗，并在成年后测试其对放射状迷宫行为习得、赫布-威廉姆斯迷宫中问题解决行为、性行为表现和睡眠-觉醒模式的影响。用氯米帕明治疗的大鼠体重减轻。在两个迷宫中的多项测量中未发现新生期药物治疗有影响。在所有三个治疗组中，射精大鼠的性行为潜伏期更长，用氯米帕明治疗的大鼠射精次数更少。在成年大鼠24小时睡眠-觉醒记录期间，用氯米帕明治疗的大鼠比对照组睡眠的时间更长。
