Moreira J C, Wannmacher C M, Costa S M, Wajner M
Departamento de Bioquímica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Brasil.
Pharmacol Biochem Behav. 1989 Apr;32(4):885-90. doi: 10.1016/0091-3057(89)90053-1.
Sustained levels of proline comparable to those of human type II hyperprolinemia were achieved in blood and brain of rats subcutaneous proline administration twice a day from the 6th till the 28th day of life. Control rats were treated with saline in the same volumes. Behavioral studies using aversive and nonaversive tasks were performed one week or one month after treatment. Proline treatment did not affect rats' performance in the inhibitory avoidance task, but reduced significantly habituation in the open field. Our results seem to indicate that early postnatal administration of proline to rats affects habituation to a novel environment. If this happens to be so the present tendency to consider hyperprolinemia as a benign condition should be revised.
从出生后第6天到第28天，每天给大鼠皮下注射脯氨酸两次，在其血液和大脑中实现了与人类II型高脯氨酸血症相当的持续脯氨酸水平。对照大鼠用相同体积的生理盐水处理。在治疗后一周或一个月，使用厌恶性和非厌恶性任务进行行为研究。脯氨酸处理不影响大鼠在抑制性回避任务中的表现，但显著降低了旷场实验中的习惯化。我们的结果似乎表明，在大鼠出生后早期给予脯氨酸会影响对新环境的习惯化。如果确实如此，那么目前将高脯氨酸血症视为良性疾病的倾向应该修正。
