小鼠骨髓瘤细胞系中一个不等姐妹染色单体交换位点的核苷酸序列。
Nucleotide sequence of an unequal sister chromatid exchange site in a mouse myeloma cell line.
作者信息
Katzenberg D R, Tilley S A, Birshtein B K
机构信息
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
出版信息
Mol Cell Biol. 1989 Mar;9(3):1324-6. doi: 10.1128/mcb.9.3.1324-1326.1989.
Abstract
The mouse myeloma cell line MPC 11 carries two C gamma 2a immunoglobulin heavy-chain genes on the expressed chromosome, a duplication shown to have occurred through unequal sister chromatid exchange (USCE). In the present report, we present the nucleotide sequence of the USCE joint and show that both breaks occurred within tracts of repeated TC dinucleotides. Additional TC dinucleotide tracts and two oligonucleotide segments (N sequences) were inserted at the USCE site.
摘要
小鼠骨髓瘤细胞系MPC 11在其表达染色体上携带两个Cγ2a免疫球蛋白重链基因，这种重复现象已被证明是通过不等姐妹染色单体交换（USCE）发生的。在本报告中，我们给出了USCE连接处的核苷酸序列，并表明两个断裂均发生在重复的TC二核苷酸序列内。在USCE位点还插入了额外的TC二核苷酸序列和两个寡核苷酸片段（N序列）。
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