Ang Bryan Chin Hou, Foo Reuben Chao Ming, Lim Edmund Wei Long, Tan Mellisa Mei Hui, Nah Gerard Kwang Ming, Thean Lennard See Yin, Tan Clement Woon Teck, Zhao Paul Song Bo
From the Vision Performance Centre (Ang, Lim, Nah, Tan, Zhao), the Military Medicine Institute, Singapore Armed Forces, National Healthcare Group Eye Institute (Ang), Tan Tock Seng Hospital, the Singapore National Eye Centre (Foo), the DSO National Laboratories (Tan), Defence Medical and Environmental Research Institute, the W Eye Clinic (Nah), the Department of Ophthalmology (Nah, Thean, Tan, Zhao), the National University Health System, and the Department of Ophthalmology (Thean), Jurong Health Services, Singapore.
From the Vision Performance Centre (Ang, Lim, Nah, Tan, Zhao), the Military Medicine Institute, Singapore Armed Forces, National Healthcare Group Eye Institute (Ang), Tan Tock Seng Hospital, the Singapore National Eye Centre (Foo), the DSO National Laboratories (Tan), Defence Medical and Environmental Research Institute, the W Eye Clinic (Nah), the Department of Ophthalmology (Nah, Thean, Tan, Zhao), the National University Health System, and the Department of Ophthalmology (Thean), Jurong Health Services, Singapore.
J Cataract Refract Surg. 2016 May;42(5):710-6. doi: 10.1016/j.jcrs.2016.01.047.
To assess the incidence and risk factors for early corneal haze after myopic photorefractive keratectomy (PRK).
Tertiary eye center, Singapore.
Retrospective case series.
The refractive results and corneal haze severity 3 months after PRK were analyzed. Eyes were categorized into 4 groups based on haze severity. Multivariate ordinal logistic regression analysis adjusting for age, ethnicity, sex, use of intraoperative mitomycin-C (MMC), preoperative sphere, and preoperative cylinder was performed.
The study reviewed data from 177 patients (347 eyes) with a mean age of 22.6 years ± 4.1 (SD). The majority of the patients were Chinese (98.3%) and men (98.3%). The mean preoperative spherical equivalent (SE) was -3.34 ± 1.19 diopters (D). One hundred thirty-five eyes (38.9%) had PRK with MMC. Ten eyes (2.9%) had enhancement surgery. The overall efficacy index was 0.88 and the safety index was 1.07. At 3 months, 187 eyes (53.9%) had no haze, 76 eyes (21.9%) had a haze grade of more than 0 and less than 1, 76 eyes (21.9%) had a haze grade of 1 or more and less than 2, and 8 eyes (2.3%) had grade 2 haze. Higher degrees of myopia (odds ratio [OR], 1.36; 95% confidence interval [CI], 1.13-1.63; P = .001) and astigmatism (OR, 1.56; 95% CI, 1.09-2.24; P = .014) were associated with increased severity of corneal haze, whereas older age (OR, 0.94; 95% CI, 0.88-0.99; P = .023) had a protective effect.
Myopia and astigmatism were associated with increased severity of haze, and older age was protective against early corneal haze development after PRK in an Asian population.
None of the authors has a financial or proprietary interest in any material or method mentioned.
评估近视性准分子激光原位角膜磨镶术（PRK）后早期角膜混浊的发生率及危险因素。
新加坡三级眼科中心。
回顾性病例系列研究。
分析PRK术后3个月的屈光结果及角膜混浊严重程度。根据混浊严重程度将眼睛分为4组。进行多变量有序逻辑回归分析，对年龄、种族、性别、术中使用丝裂霉素C（MMC）、术前球镜度数和术前柱镜度数进行校正。
该研究回顾了177例患者（347只眼）的数据，平均年龄为22.6岁±4.1（标准差）。大多数患者为华裔（98.3%）和男性（98.3%）。术前平均等效球镜度数（SE）为-3.34±1.19屈光度（D）。135只眼（38.9%）接受了使用MMC的PRK手术。10只眼（2.9%）接受了增效手术。总体疗效指数为0.88，安全指数为1.07。术后3个月时，187只眼（53.9%）无混浊，76只眼（21.9%）混浊程度大于0且小于1级，76只眼（21.9%）混浊程度为1级或以上且小于2级，8只眼（2.3%）混浊程度为2级。更高的近视度数（比值比[OR]，1.36；95%置信区间[CI]，1.13 - 1.63；P = 0.001）和散光度数（OR，1.56；95% CI，1.09 - 2.24；P = 0.014）与角膜混浊严重程度增加相关，而年龄较大（OR，0.94；95% CI，0.88 - 0.99；P = 0.023）具有保护作用。
在亚洲人群中，近视和散光与混浊严重程度增加相关，年龄较大对PRK术后早期角膜混浊的发生具有保护作用。
作者均未对文中提及的任何材料或方法拥有财务或专利权益。
