Wikenheiser Andrew M, Schoenbaum Geoffrey
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA.
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA; the Department of Anatomy and Neurobiology, University of Maryland, Baltimore, Maryland 21201, USA; and the Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Nat Rev Neurosci. 2016 Aug;17(8):513-23. doi: 10.1038/nrn.2016.56. Epub 2016 Jun 3.
The hippocampus and the orbitofrontal cortex (OFC) both have important roles in cognitive processes such as learning, memory and decision making. Nevertheless, research on the OFC and hippocampus has proceeded largely independently, and little consideration has been given to the importance of interactions between these structures. Here, evidence is reviewed that the hippocampus and OFC encode parallel, but interactive, cognitive 'maps' that capture complex relationships between cues, actions, outcomes and other features of the environment. A better understanding of the interactions between the OFC and hippocampus is important for understanding the neural bases of flexible, goal-directed decision making.
海马体和眶额皮质（OFC）在诸如学习、记忆和决策等认知过程中都发挥着重要作用。然而，对眶额皮质和海马体的研究在很大程度上是独立进行的，很少有人考虑这些结构之间相互作用的重要性。在此，我们回顾相关证据，即海马体和眶额皮质编码并行但相互作用的认知“地图”，这些“地图”捕捉线索、行动、结果以及环境的其他特征之间的复杂关系。更好地理解眶额皮质和海马体之间的相互作用对于理解灵活的、目标导向决策的神经基础至关重要。
