Ólafsdóttir H Freyja, Barry Caswell, Saleem Aman B, Hassabis Demis, Spiers Hugo J
Institute of Behavioural Neuroscience, Department of Experimental Psychology, Division of Psychology and Language Sciences, University College London, London, United Kingdom.
Department of Cell and Developmental Biology, University College London, London, United Kingdom.
Elife. 2015 Jun 26;4:e06063. doi: 10.7554/eLife.06063.
Dominant theories of hippocampal function propose that place cell representations are formed during an animal's first encounter with a novel environment and are subsequently replayed during off-line states to support consolidation and future behaviour. Here we report that viewing the delivery of food to an unvisited portion of an environment leads to off-line pre-activation of place cells sequences corresponding to that space. Such 'preplay' was not observed for an unrewarded but otherwise similar portion of the environment. These results suggest that a hippocampal representation of a visible, yet unexplored environment can be formed if the environment is of motivational relevance to the animal. We hypothesise such goal-biased preplay may support preparation for future experiences in novel environments.
海马体功能的主流理论认为，位置细胞表征是在动物首次接触新环境时形成的，随后在离线状态下重播，以支持记忆巩固和未来行为。在此，我们报告称，观察食物被递送到环境中一个未被访问过的区域，会导致对应于该空间的位置细胞序列的离线预激活。对于环境中一个没有奖励但在其他方面相似的区域，未观察到这种“预播放”。这些结果表明，如果环境对动物具有动机相关性，那么即使是一个可见但未被探索的环境，海马体也可以形成相应表征。我们推测，这种目标偏向性预播放可能有助于为未来在新环境中的体验做准备。
