Zheng Zhen, Zhang Li, Zhu Tingting, Huang Jichong, Qu Yi, Mu Dezhi
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu 610041, China.
PLoS One. 2016 Jun 3;11(6):e0156662. doi: 10.1371/journal.pone.0156662. eCollection 2016.
We conducted a meta-analysis to summarize the evidence from epidemiological studies of the association between asthma and autism spectrum disorder (ASD).
A literature search was conducted using PubMed, Embase, and Cochrane library for studies published before February 2nd, 2016. Observational studies investigating the association between asthma and ASD were included. A random effects model was used to calculate the pooled risk estimates for the outcome. Subgroup analysis was used to explore potential sources of heterogeneity and publication bias was estimated using Begg's and Egger's tests.
Ten studies encompassing 175,406 participants and 8,809 cases of ASD were included in this meta-analysis. In the cross-sectional studies, the prevalence of asthma in ASD was 20.4%, while the prevalence of asthma in controls was 15.4% (P < 0.001). The pooled odds ratio (OR) for the prevalence of asthma in ASD in the cross-sectional studies was 1.26 (95% confidence interval (CI): 0.98-1.61) (P = 0.07), with moderate heterogeneity (I2 = 65.0%, P = 0.02) across studies. In the case-control studies, the pooled OR for the prevalence of asthma in ASD was 0.98 (95% CI: 0.68-1.43) (P = 0.94), and there was no evidence of an association between asthma and ASD. No evidence of significant publication bias on the association between asthma and ASD was found.
In conclusion, the results of this meta-analysis do not suggest an association between asthma and ASD. Further prospective studies ascertaining the association between asthma and ASD are warranted.
我们进行了一项荟萃分析，以总结哮喘与自闭症谱系障碍（ASD）之间关联的流行病学研究证据。
使用PubMed、Embase和Cochrane图书馆对2016年2月2日前发表的研究进行文献检索。纳入调查哮喘与ASD之间关联的观察性研究。采用随机效应模型计算该结果的合并风险估计值。进行亚组分析以探索异质性的潜在来源，并使用Begg检验和Egger检验评估发表偏倚。
该荟萃分析纳入了10项研究，共175406名参与者和8809例ASD病例。在横断面研究中，ASD患者中哮喘的患病率为20.4%，而对照组中哮喘的患病率为15.4%（P<0.001）。横断面研究中ASD患者哮喘患病率的合并比值比（OR）为1.26（95%置信区间（CI）：0.98 - 1.61）（P = 0.07），各研究间存在中度异质性（I2 = 65.0%，P = 0.02）。在病例对照研究中，ASD患者哮喘患病率的合并OR为0.98（95%CI：0.68 - 1.43）（P = 0.94），且没有证据表明哮喘与ASD之间存在关联。未发现哮喘与ASD之间关联存在显著发表偏倚的证据。
总之，该荟萃分析结果未表明哮喘与ASD之间存在关联。有必要进行进一步的前瞻性研究以确定哮喘与ASD之间的关联。
