Curtis R, Fraser H, Foster J D, Scott J R
Comparative Ophthalmology Unit, Animal Health Trust, Newmarket, Suffolk, UK.
Neuropathol Appl Neurobiol. 1989 Jan-Feb;15(1):75-89. doi: 10.1111/j.1365-2990.1989.tb01151.x.
Retinal degeneration was produced using the 79A strain of scrapie injected intracerebrally into mice of the MM inbred strain, and studied by electroretinography and light and electron microscopy during the preclinical and clinical phases of the disease. The changes in the electroretinogram (ERG), detectable in some mice at 118 days postinjection (d.p.i.), appeared to coincide with the earliest morphological evidence of photoreceptor damage. In the early stages there was a progressive reduction of b-wave amplitude without marked loss of retinal sensitivity or significant change in a- and b-wave peak implicit times. Extinction of the ERG, observed in half the mice examined at 144 d.p.i., approximated to a stage of the retinopathy in which the outer nuclear layer was reduced to about four rows of nuclei. Early morphological changes suggested that the primary lesion involved the integrity of the photoreceptor as a whole, the electrophysiological findings reflecting a primary loss of light sensitive tissue rather than impairment of the transduction mechanism or neurotransmission.
将羊瘙痒病79A毒株脑内注射到近交系MM小鼠中诱导产生视网膜变性，并在疾病的临床前期和临床期通过视网膜电图、光学显微镜和电子显微镜进行研究。在注射后118天（d.p.i.），部分小鼠的视网膜电图（ERG）变化似乎与光感受器损伤的最早形态学证据一致。早期阶段，b波振幅逐渐降低，而视网膜敏感性无明显丧失，a波和b波峰潜时无显著变化。在144 d.p.i.检查的半数小鼠中观察到ERG熄灭，这大致相当于视网膜病变的一个阶段，此时外核层减少至约四排细胞核。早期形态学变化表明，原发性病变累及整个光感受器的完整性，电生理结果反映了光敏感组织的原发性丧失，而非转导机制或神经传递受损。
