Kozlowski P B, Moretz R C, Carp R I, Wisniewski H M
Acta Neuropathol. 1982;56(1):9-12. doi: 10.1007/BF00691175.
Retinal damages in mice infected with scrapie are reported. The effects ranged from no histopathological changes, through partial loss of the outer nuclear layer (ONL) to the most severe changes with complete loss of ONL cells and photoreceptors. For the most part, cells of inner nuclear and ganglion layers were spared. These changes were found in 23% of C57BL/6J mice injected with the ME7 strain of scrapie and in 28.5% of VM mice injected with the 87 V strain, while no changes were found in 13 IM mice injected with the 87 V strain of scrapie. The possible relation of these changes to scrapie infection and to light induced retinopathy is discussed.
据报道，感染瘙痒病的小鼠会出现视网膜损伤。其影响范围从无组织病理学变化，到外核层（ONL）部分缺失，再到最严重的变化，即ONL细胞和光感受器完全丧失。在大多数情况下，内核层和神经节层的细胞未受影响。在注射了瘙痒病ME7毒株的23%的C57BL/6J小鼠以及注射了87V毒株的28.5%的VM小鼠中发现了这些变化，而在注射了瘙痒病87V毒株的13只IM小鼠中未发现变化。本文讨论了这些变化与瘙痒病感染以及光诱导视网膜病变之间的可能关系。
