Li Li, Liang Wangqun, Ye Ting, Chen Zhenyan, Zuo Xuezhi, Du Xiang, Qian Kun, Zhang Chunxiu, Hu Xiangrong, Li Junhua, Wang Le, Ma Zufu, Yao Ying
Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
PLoS One. 2016 Jun 3;11(6):e0156423. doi: 10.1371/journal.pone.0156423. eCollection 2016.
Residual renal function (RRF) is an important prognostic factor for peritoneal dialysis patients as it influences the quality of life and mortality. This study was conducted to explore the potential factors correlated with RRF. A cross-sectional study was conducted by recruiting 155 patients with residual GFR more than 1mL/min per 1.73m2 at the initiation of peritoneal dialysis. We collected the demographic characteristics, nutritional markers and biochemical parameters of all participants, and analyzed the correlation between these variables and residual GFR as well. The odds ratio of RRF loss associated with each of the nutritional markers and biochemical parameters were estimated by logistic regression model. The residual GFR was negatively correlated with serum phosphate (ORQ3 = 2.67, 95%CI: 1.03-6.92; ORQ4 = 3.45, 95%CI: 1.35-9.04), magnesium (ORQ4 = 3.77, 95%CI: 1.48-3.63), and creatinine (ORQ3 = 2.93, 95%CI: 1.09-7.88; ORQ4 = 8.64 95%CI: 2.79-26.78), while positively associated with normalized protein catabolic rate (ORQ3 = 0.24, 95%CI: 0.09-0.65; ORQ4 = 0.11, 95%CI: 0.03-0.35), 24 hours urine volume(ORQ1 = 22.87, 95%CI: 2.76-189.24; ORQ3 = 0.08, 95%CI: 0.02-0.28) and serum chlorine concentrations (ORQ1 = 5.34, 95%CI: 1.94-14.68; ORQ4 = 0.28, 95%CI: 0.09-0.85), respectively. Our study suggested that the nutritional markers and biochemical parameters, though not all, but at least in part were closely correlated with RRF in peritoneal dialysis patients.
残余肾功能（RRF）是腹膜透析患者重要的预后因素，因为它会影响生活质量和死亡率。本研究旨在探索与RRF相关的潜在因素。通过招募155例在开始腹膜透析时残余肾小球滤过率（GFR）超过1mL/（min·1.73m²）的患者进行了一项横断面研究。我们收集了所有参与者的人口统计学特征、营养指标和生化参数，并分析了这些变量与残余GFR之间的相关性。通过逻辑回归模型估计与每个营养指标和生化参数相关的RRF丧失的比值比。残余GFR与血清磷（ORQ3 = 2.67，95%CI：1.03 - 6.92；ORQ4 = 3.45，95%CI：1.35 - 9.04）、镁（ORQ4 = 3.77，95%CI：1.48 - 3.63）和肌酐（ORQ3 = 2.93，95%CI：1.09 - 7.88；ORQ4 = 8.64，95%CI：2.79 - 26.78）呈负相关，而分别与标准化蛋白分解代谢率（ORQ3 = 0.24，95%CI：0.09 - 0.65；ORQ4 = 0.11，95%CI：0.03 - 0.35）、2小时尿量（ORQ1 = 22.87，95%CI：2.76 - 189.24；ORQ3 = 0.08，95%CI：0.02 - 0.28）和血清氯浓度（ORQ1 = 5.34，95%CI：1.94 - 14.68；ORQ4 = 0.28，95%CI：0.09 - 0.85）呈正相关。我们的研究表明，营养指标和生化参数虽然并非全部，但至少部分与腹膜透析患者的RRF密切相关。
