Ma C, Zhang Y, Li X, Zhang J, Chen K, Liang Y, Chen Y, Liu Z, Zhang Z
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Beijing Ageing Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, China.
Eur J Neurol. 2016 Sep;23(9):1415-25. doi: 10.1111/ene.13052. Epub 2016 Jun 4.
Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease. However, it is unknown whether rs405509 T allele synergizes with the APOE ε4 allele in influencing cognition and brain structure.
We analyzed the interaction effect of the rs405509 T allele and the APOE ε4 allele on cognitive ability and brain gray matter volume among elderly people. The subjects were grouped into four groups according to APOE and rs405509 genotypes.
Significant interaction effects were found between rs405509 and APOE on general mental status, memory and attention. Analysis of the whole brain gray matter showed a significantly positive interaction effect between rs405509and APOE on the right inferior temporal gyrus and right fusiform gyrus (alphasim correction P < 0.001). In addition, there was a significant relationship between cognitive ability and gray matter volume.
The data indicate that the APOE rs405509 T homozygote modulates the effect of APOE ε4 on both cognitive performance and brain gray matter structure.
有证据表明，载脂蛋白E（APOE）启动子单核苷酸多态性rs405509的T等位基因是阿尔茨海默病的一个危险因素。然而，rs405509 T等位基因是否与APOE ε4等位基因协同影响认知和脑结构尚不清楚。
我们分析了rs405509 T等位基因与APOE ε4等位基因对老年人认知能力和脑灰质体积的相互作用。根据APOE和rs405509基因型将受试者分为四组。
发现rs405509与APOE在一般精神状态、记忆和注意力方面存在显著的相互作用。全脑灰质分析显示，rs405509与APOE在右侧颞下回和右侧梭状回存在显著的正向相互作用（α 校正P<0.001）。此外，认知能力与灰质体积之间存在显著关系。
数据表明，APOE rs405509 T纯合子调节APOE ε4对认知表现和脑灰质结构的影响。
