Löfgren Stefan
Karolinska Institutet, St. Erik Eye Hospital, Polhemsgatan 50, 11282 Stockholm, Sweden.
Exp Eye Res. 2017 Mar;156:112-116. doi: 10.1016/j.exer.2016.05.026. Epub 2016 May 31.
Despite being a treatable disease, cataract is still the leading cause for blindness in the world. Solar ultraviolet radiation is epidemiologically linked to cataract development, while animal and in vitro studies prove a causal relationship. However, the pathogenetic pathways for the disease are not fully understood and there is still no perfect model for human age related cataract. This non-comprehensive overview focus on recent developments regarding effects of solar UV radiation wavebands on the lens. A smaller number of fundamental papers are also included to provide a backdrop for the overview. Future studies are expected to further clarify the cellular and subcellular mechanisms for UV radiation-induced cataract and especially the isolated or combined temporal and spatial effects of UVA and UVB in the pathogenesis of human cataract. Regardless of the cause for cataract, there is a need for advances in pharmaceutical or other treatment modalities that do not require surgical replacement of the lens.
尽管白内障是一种可治疗的疾病，但它仍是全球失明的主要原因。从流行病学角度来看，太阳紫外线辐射与白内障的发展有关，而动物和体外研究证明了两者之间的因果关系。然而，该疾病的发病机制尚未完全明确，目前仍没有完善的人类年龄相关性白内障模型。本综述聚焦于太阳紫外线辐射波段对晶状体影响的最新进展。同时纳入了少量基础论文以作为综述的背景支撑。未来的研究有望进一步阐明紫外线辐射诱发白内障的细胞和亚细胞机制，尤其是UVA和UVB在人类白内障发病机制中的单独或联合的时空效应。无论白内障的病因如何，都需要在药物或其他治疗方式上取得进展，而无需通过手术更换晶状体。
